Evidence map›Paper›PMID 39384978›Full record

ArticleCommunications biology2024

Gene editing of NCF1 loci is associated with homologous recombination and chromosomal rearrangements.

Federica Raimondi, Kah Mun Siow, Dominik Wrona, Carla Fuster-García, Oleksandr Pastukhov, Michael Schmitz, Katja Bargsten, Lucas Kissling, Daan C Swarts, Geoffroy Andrieux and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Gene Therapy for Inherited Liver Disease: To Add or to Edit.International journal of molecular sciences · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Federica RaimondiDivision of Gene and Cell Therapy, Institute for Regenerative Medicine, University of Zurich (Schlieren Campus), Schlieren, Switzerland.
Kah Mun SiowDivision of Gene and Cell Therapy, Institute for Regenerative Medicine, University of Zurich (Schlieren Campus), Schlieren, Switzerland.ORCID 0000-0003-4609-9096
Dominik WronaDivision of Gene and Cell Therapy, Institute for Regenerative Medicine, University of Zurich (Schlieren Campus), Schlieren, Switzerland.
Carla Fuster-GarcíaInstitute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0002-4209-7248
Oleksandr PastukhovDivision of Gene and Cell Therapy, Institute for Regenerative Medicine, University of Zurich (Schlieren Campus), Schlieren, Switzerland.
Michael SchmitzDepartment of Biochemistry, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-3216-7350
Katja BargstenDepartment of Biochemistry, University of Zurich, Zurich, Switzerland.
Lucas KisslingDepartment of Biochemistry, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-4989-0695
Daan C SwartsDepartment of Biochemistry, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-4412-9191
Geoffroy AndrieuxInstitute for Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0002-5389-9481
Toni CathomenInstitute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0002-7757-4630
Ute ModlichDivision of Gene and Cell Therapy, Institute for Regenerative Medicine, University of Zurich (Schlieren Campus), Schlieren, Switzerland.
Martin JinekDepartment of Biochemistry, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-7601-210X
Ulrich Siler *School of Life Sciences, Institute for Pharma Technology, University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland.ORCID 0000-0002-2458-2629
Janine Reichenbach *Division of Gene and Cell Therapy, Institute for Regenerative Medicine, University of Zurich (Schlieren Campus), Schlieren, Switzerland. janine.reichenbach@irem.uzh.ch.ORCID 0000-0002-9008-1312

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 31003A_182567Universität Zürich (University of Zurich) FK-17-041Universität Zürich (University of Zurich) FK-17-053
6 · The paper itself

Abstract

CRISPR-based genome editing of pseudogene-associated disorders, such as p47

Indexed as

Gene EditingHomologous RecombinationNADPH OxidasesCell LineChromosome AberrationsCRISPR-Cas SystemsGranulomatous Disease, ChronicHumansNADPH Oxidasesneutrophil cytosolic factor 1

Identifiers

PMID39384978
PMCPMC11464842

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.