Evidence map›Paper›PMID 39384971›Full record

ArticleCommunications biology2024

Glial cells undergo rapid changes following acute chemogenetic manipulation of cortical layer 5 projection neurons.

Auguste Vadisiute, Elise Meijer, Rajeevan Narayanan Therpurakal, Marissa Mueller, Florina Szabó, Fernando Messore, Alfonsas Jursenas, Oliver Bredemeyer, Lukas B Krone, Ed Mann and 3 more

Abstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Auguste VadisiuteDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, United Kingdom. auguste.vadisiute@dpag.ox.ac.uk.ORCID 0000-0002-6722-7504
Elise MeijerDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, United Kingdom.ORCID 0000-0002-4812-3275
Rajeevan Narayanan TherpurakalDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, United Kingdom.
Marissa MuellerDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, United Kingdom.ORCID 0000-0002-9729-8311
Florina SzabóDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, United Kingdom.
Fernando MessoreDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, United Kingdom.ORCID 0000-0002-5365-2606
Alfonsas JursenasBaltic Institute of Advanced Technology, Vilnius, Lithuania.
Oliver BredemeyerSt John's College, University of Oxford, St Giles', Oxford, United Kingdom.ORCID 0000-0002-4867-4827
Lukas B KroneDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, United Kingdom.
Ed MannDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, United Kingdom.ORCID 0000-0002-2468-7148
Vladyslav VyazovskiyDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, United Kingdom.ORCID 0000-0002-4336-6681
Anna Hoerder-SuabedissenDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, United Kingdom.ORCID 0000-0003-1953-7871
Zoltán MolnárDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, OX1 3PT, United Kingdom. zoltan.molnar@dpag.ox.ac.uk.ORCID 0000-0002-6852-6004

Funding

EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 890457-L6bMedical Research Council MR/S01134X/1Oxford University | St. John's College, University of Oxford (St John's College, University of Oxford) 21138077RCUK | Medical Research Council (MRC) G00900901Wellcome Trust
6 · The paper itself

Abstract

Bidirectional communication between neurons and glial cells is crucial to establishing and maintaining normal brain function. Some of these interactions are activity-dependent, yet it remains largely unexplored how acute changes in neuronal activity affect glial-to-neuron and neuron-to-glial dynamics. Here, we use excitatory and inhibitory designer receptors exclusively activated by designer drugs (DREADD) to study the effects of acute chemogenetic manipulations of a subpopulation of layer 5 cortical projection and dentate gyrus neurons in adult (Rbp4

Indexed as

ClozapineNeurogliaNeuronsAnimalsCerebral CortexMaleMiceMice, TransgenicParvalbuminsClozapineclozapine N-oxideParvalbumins

Identifiers

PMID39384971
PMCPMC11464517

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.