ArticleMolecular psychiatry2025
Sex/gender effects of glial reactivity on preclinical Alzheimer's disease pathology.
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Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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22citing papers in PubMed, 2 pooled it
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neuroinflammatory markers sTREM2 and YKL-40 in association with Alzheimer's disease pathology: a systematic review and meta-analysis.Molecular psychiatry · 2026Pooled it
- Association of Alzheimer's disease progression with YKL40 levels in peripheral blood and cerebrospinal fluid: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- Sex-specific regulation of angiogenin in Alzheimer's disease.Molecular psychiatry · 2026Article
- Education Moderates the Biomarker-Cortical-Thickness Relationship in Females With Cognitive Decline: A Descriptive Study With Sex Comparisons.Journal of clinical neurology (Seoul, Korea) · 2026Article
- A non-canonical androgen signaling pathway drives microglial activation and tau pathology in females.Research square · 2026Article
- Sex-specific associations between astrocytic reactivity and cognitive decline in unimpaired elderly.bioRxiv : the preprint server for biology · 2026Article
- Plasma proteomic profiles of Alzheimer's disease and neurodegeneration in African cohorts.Nature communications · 2026Article
- The complex of gut microbial metabolites and sex hormones in Alzheimer's disease.Seminars in immunopathology · 2026Review
- Sleep disturbances and Alzheimer's disease: a multiscale approach from exposome to neurobiology and precision medicine.GeroScience · 2026Review
- Sex differences in Alzheimer's disease plasma biomarker levels and clinical utility.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Sex and gender-related differences in neurological diseases: current challenges and recommendations for clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Increased levels of GFAP and purinergic P2X7 receptor in Alzheimer's disease brain are associated with Aβ, tau pathologies and synaptic loss.Alzheimer's research & therapy · 2025Article
- CHI3L1: An Emerging Player in Neuroinflammation and Neurodegeneration.Molecular neurobiology · 2025Review
- Prognostic value of plasma glial fibrillary acidic protein in cognitively unimpaired older adults: Results from the A4 study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Sex differences in Alzheimer's disease CSF biomarkers and their association with Aβ pathology on PET in cognitively unimpaired individuals.Alzheimer's research & therapy · 2025Article
- Sex-specific effects of fecal microbiota transplantation on TBI-exacerbated Alzheimer's pathology in mice.bioRxiv : the preprint server for biology · 2025Article
- Special Issue: "New Trends in Alzheimer's Disease Research: From Molecular Mechanisms to Therapeutics: 2nd Edition".International journal of molecular sciences · 2025Article
- Sexual Dimorphism in Levodopa-Induced Dyskinesia Following Parkinson's Disease: Uncharted Territory.The European journal of neuroscience · 2025Review
- Glioinflammation: disease-associated microglia and astrocytes in psychiatric disorders, neurodegeneration, and senescence.Frontiers in cellular neuroscience · 2025Review
- Brain MRI signatures across sex and CSF Alzheimer's disease biomarkers.Brain communications · 2025Article
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Authors and funding
16 authors.
Clara Vila-Castelar *Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.ORCID 0000-0002-8779-1487
Muge Akinci *Barcelona Institute for Global Health, IS GLOBAL, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.
Eleni PalpatzisBarcelona Institute for Global Health, IS GLOBAL, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.ORCID 0000-0001-8478-273X
Pablo Aguilar-DominguezBarcelona Institute for Global Health, IS GLOBAL, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain.
Gregory OpertoBarcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.
Gwendlyn KollmorgenRoche Diagnostics GmbH, Nonnenwald 2, 82377, Penzberg, Germany.
Clara Quijano-RubioRoche Diagnostics International Ltd, Forrenstrasse 2, 6343, Rotkreuz, Switzerland.ORCID 0000-0001-9050-3282
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Wallinsgatan 6, 431 41, Mölndal, Sweden.ORCID 0000-0002-1890-4193
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Wallinsgatan 6, 431 41, Mölndal, Sweden.ORCID 0000-0003-3930-4354
Carles FalconBarcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.ORCID 0000-0001-5564-2025
Karine FauriaBarcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain. kfauria@barcelonabeta.org.
Juan Domingo GispertBarcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.ORCID 0000-0002-6155-0642
Oriol Grau-RiveraBarcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.
Marc Suárez-CalvetBarcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Carrer de Wellington, 30, 08005, Barcelona, Spain.ORCID 0000-0002-2993-569X
Eider M Arenaza-UrquijoBarcelona Institute for Global Health, IS GLOBAL, Carrer del Dr. Aiguader, 88, Ciutat Vella, 08003, Barcelona, Spain. eider.arenaza@isglobal.org.ORCID 0000-0001-7016-7576
ALFA study
Funding
Examining the impact of sex and hormones on the progression of autosomal dominant Alzheimer's diseaseK99AG073452 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI VILA CASTELAR, CLARA · 2022 to 2023
$268kAlzheimer's Association AARG 2019-AARG-644641Alzheimer's Association AARG 2019-AARG-644641-RAPIDEU Joint Programme - Neurodegenerative Disease Research (Programi i Përbashkët i BE-së për Kërkimet mbi Sëmundjet Neuro-degjeneruese) JPND2021-00694EU Joint Programme - Neurodegenerative Disease Research (Programi i Përbashkët i BE-së për Kërkimet mbi Sëmundjet Neuro-degjeneruese) JPND2022-138"la Caixa" Foundation (Caixa Foundation) 100010434Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) PI19/00155Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) PI22/00456NIA NIH HHS K99 AG073452U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) K99AG073452
Abstract
Glial reactivity may contribute to sex/gender differences in Alzheimer's disease (AD) pathophysiology. Here, we investigated the differential effect of cerebrospinal fluid (CSF) glial markers on AD pathology and neurodegeneration by sex/gender among cognitively unimpaired older adults at increased risk of developing AD. We included 397 participants from the ALFA+ cohort with CSF Aβ
Indexed as
Alzheimer DiseaseNeurogliaAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersChitinase-3-Like Protein 1Cohort StudiesFemaleGlial Fibrillary Acidic ProteinHippocampusHumansMagnetic Resonance ImagingMaleMembrane GlycoproteinsMiddle AgedAmyloid beta-PeptidesBiomarkersCHI3L1 protein, humanChitinase-3-Like Protein 1Glial Fibrillary Acidic ProteinMembrane GlycoproteinsPeptide FragmentsReceptors, Immunologictau ProteinsTREM2 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.