ArticleCommunications engineering2024
Biomechanical changes occur in myopic choroidal stroma and mirror those in the adjacent sclera.
Article in Communications engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Perforating scleral vessel angular metrics as a structural biomarker of myopic choroidal neovascularisation.Eye (London, England) · 2026Article
- Biomechanics of the retina: experimental and clinical perspectives.Biomedical engineering online · 2026Review
- Stereophotographic Assessment of Intraocular Pressure Reduction in Myopic Eyes with Glaucoma-Compatible Optic Neuropathy.Ophthalmology and therapy · 2026Article
- Investigation of 3D choroidal components in myopic populations using ultra-widefield OCTA.Eye (London, England) · 2026Article
- Environmental exposure to perchlorate, nitrate, and thiocyanate in relation to myopia in adolescents: a cross-sectional NHANES study.European journal of medical research · 2026Article
- Interaction Between Near Work and Narrowband Light on Choroidal Thickness.Investigative ophthalmology & visual science · 2026Article
- Effects of different powers of repeated low-level red light on form-deprivation myopia inhibition in guinea pigs.Scientific reports · 2025Article
- Effects of Imposed Defocus on Inhibitor of DNA-Binding Gene Expression in Chick Posterior Ocular Tissues.Cells · 2025Article
- Mechanisms Underlying Myopia Progression from Visual Signaling to Metabolic Remodeling in Retina.JMA journal · 2025Review
- Microindentation reveals softening of the equatorial and anterior sclera during early myopia development in tree shrew eyes.Acta biomaterialia · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Retina-derived growth signals relayed from the choroid to the sclera cause remodeling of the extracellular scleral matrix, resulting in myopic ocular elongation. However, to the best of our knowledge, no studies have assessed changes in choroidal stromal biomechanical properties during myopia progression. Here we utilized 7 µm-resolution scanning acoustic microscopy (SAM) to assess biomechanical properties (bulk modulus (K) and mass density (rho)) of choroidal stroma from guinea pig eyes with form-deprivation (FD) induced myopia. The choroidal stroma had considerable intrinsic strength arising from its biomechanical properties and these were differentially affected by myopia in central and peripheral regions. Choroidal stromal biomechanical values were also highly correlated with those in adjacent scleral regions, and the choroidal stromal-scleral association was stronger in myopic eyes. Biomechanical changes observed in the choroidal stroma of myopic eyes were mirrored to those observed in the adjacent sclera. These findings suggest that choroidal stromal remodeling may accompany myopia and open the door to the source of the signals that cause scleral remodeling in myopia.
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Registered trials
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