Evidence map›Paper›PMID 39384819›Full record

ReviewNPJ systems biology and applications2024

Systems immunology approaches to study T cells in health and disease.

Aaron Yang, Amanda C Poholek

Abstract readReview
In one paragraph

Review in NPJ systems biology and applications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. [Ubiquitination-mediated regulation of T cell homeostasis and autoimmune diseases].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Aaron YangDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Amanda C PoholekDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. poholeka@pitt.edu.ORCID http://orcid.org/0000-0002-5587-8940

Funding

Project 5: Microenvironment manipulation using anti-angiogenics to improve immunotherapy in melanomaP50CA254865 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, HONG · 2021 to 2025
$10.4M
Training in Cellular & Molecular Mechanisms of Tumor RejectionT32CA082084 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert J Binder, Dario AA Vignali · 1999 to 2026
$9.2M
Lung-specific expression and function of Blimp-1 in T cells impacting allergic asthmaR01AI153104 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POHOLEK, AMANDA CATHERINE · 2021 to 2025
$2.6M
Dissecting the role of hypoxia in T cell differentiation in cancerR01CA277473 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Greg M. Delgoffe, Yana Najjar · 2023 to 2026
$2.4M
Blimp-1-mediated Th2 cell development in the lung impacting allergic airway inflammationR21AI135027 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POHOLEK, AMANDA CATHERINE · 2018 to 2019
$409k
NCI NIH HHS P50 CA254865NCI NIH HHS R01 CA277473NCI NIH HHS T32 CA082084NIAID NIH HHS R01 AI153104NIAID NIH HHS R21 AI135027U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P50 CA254865 Melanoma and Skin Cancer SPORE (CEP)U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 1R01AI153104U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 5R21AI135027
6 · The paper itself

Abstract

T cells are dynamically regulated immune cells that are implicated in a variety of diseases ranging from infection, cancer and autoimmunity. Recent advancements in sequencing methods have provided valuable insights in the transcriptional and epigenetic regulation of T cells in various disease settings. In this review, we identify the key sequencing-based methods that have been applied to understand the transcriptomic and epigenomic regulation of T cells in diseases.

Indexed as

T-LymphocytesAnimalsEpigenesis, GeneticEpigenomicsHumansImmunoinformaticsNeoplasmsSystems BiologyTranscriptome

Identifiers

PMID39384819
PMCPMC11464710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.