Evidence map›Paper›PMID 39384814›Full record

ArticleNature communications2024

CBFA2T3-GLIS2 mediates transcriptional regulation of developmental pathways through a gene regulatory network.

Elizabeth A R Garfinkle, Pratima Nallagatla, Binay Sahoo, Jinjun Dang, Mohammad Balood, Anitria Cotton, Camryn Franke, Sharnise Mitchell, Taylor Wilson, Tanja A Gruber

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elizabeth A R Garfinkle *Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Pratima Nallagatla *Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-5488-7378
Binay SahooDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-0362-9130
Jinjun DangDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Mohammad BaloodDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Anitria CottonDivision of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Camryn FrankeDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Sharnise MitchellDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Taylor WilsonDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-2040-7655
Tanja A GruberDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. tagruber@stanford.edu.ORCID 0000-0003-1072-7257

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CBFA2T3-GLIS2 is a fusion oncogene found in pediatric acute megakaryoblastic leukemia that is associated with a poor prognosis. We establish a model of CBFA2T3-GLIS2 driven acute megakaryoblastic leukemia that allows the distinction of fusion specific changes from those that reflect the megakaryoblast lineage of this leukemia. Using this model, we map fusion genome wide binding that in turn imparts the characteristic transcriptional signature. A network of transcription factor genes bound and upregulated by the fusion are found to have downstream effects that result in dysregulated signaling of developmental pathways including NOTCH, Hedgehog, TGFβ, and WNT. Transcriptional regulation is mediated by homo-dimerization and binding of the ETO transcription factor through the nervy homology region 2. Loss of nerve homology region 2 abrogated the development of leukemia, leading to downregulation of JAK/STAT, Hedgehog, and NOTCH transcriptional signatures. These data contribute to the understanding of CBFA2T3-GLIS2 mediated leukemogenesis and identify potential therapeutic vulnerabilities for future studies.

Indexed as

Gene Regulatory NetworksOncogene Proteins, FusionAnimalsGene Expression Regulation, DevelopmentalHedgehog ProteinsHumansKruppel-Like Transcription FactorsMiceReceptors, NotchSignal TransductionTranscription FactorsGLIS2 protein, humanHedgehog ProteinsKruppel-Like Transcription FactorsOncogene Proteins, FusionReceptors, NotchTranscription Factors

Identifiers

PMID39384814
PMCPMC11464917

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.