Evidence map›Paper›PMID 39384733›Full record

ArticleGeroScience2025

Apathy, gait slowness, and executive dysfunction (AGED) triad: opportunities to predict and delay dementia onset.

Frederico Pieruccini-Faria, Vladimir Hachinski, Surim Son, Manuel Montero-Odasso

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Frederico Pieruccini-FariaGait and Brain Lab, St. Joseph's Health London Care, Parkwood Institute and Lawson Health Research Institute, Main Building Parkwood Institute, 550 Wellington Rd, Room A3-116, London, ON, N6C 0A7, Canada.
Vladimir HachinskiDepartment of Clinical Neurological Sciences, Robarts Research Institute and University of Western Ontario, 1151 Richmond St, London, ON, N6A 3K7, Canada.
Surim SonUniversity Hospital London Health Sciences Centre, 339 Windermere Road London, London, ON, N6A 5A5, Canada.
Manuel Montero-OdassoGait and Brain Lab, St. Joseph's Health London Care, Parkwood Institute and Lawson Health Research Institute, Main Building Parkwood Institute, 550 Wellington Rd, Room A3-116, London, ON, N6C 0A7, Canada. mmontero@uwo.ca.ORCID 0000-0002-5796-2361

Funding

Canadian Consortium on Neurodegeneration in Aging FRNCNA137794CIHR MOP211220CIHR PJT153100Ontario Ministry of Research Innovation ER11-08-101Program of Experimental Medicine Research Award POEM768915Weston Family Foundation BH210118
6 · The paper itself

Abstract

This study investigates whether older adults diagnosed with the apathy, gait impairment, and executive dysfunction (AGED) triad, frequently associated with cerebrovascular disease and confounded with depression, have earlier dementia onset. We followed 322 community-dwelling older individuals (mean age 72.0 ± 6.4 years; 58.3% women) free of dementia at baseline for up to 9 years. The AGED triad was identified when gait slowness (< 1 m/s), apathy (assessed by Geriatric Depression Scale-3A with ≥ 2 items), and executive dysfunction (assessed by the 75th percentile of Trail Making Test-part B by age range) were simultaneously present. Incident dementia was diagnosed using the clinical dementia rating scale. Over the 9-year follow-up (mean 45.1 ± 28.6 months), 44 participants (13.6%) converted to dementia. Sixteen participants (5.0%) were diagnosed with AGED triad + and showed a significantly higher risk of earlier conversion to dementia compared with AGED triad- (hazard ratio = 5.08, 95%CI 2.16-11.97; p = 0.0001), as well as to those with only one AGED factor or fewer AGED factors. Hypertension and diabetes were 2 and 3 times more prevalent, respectively, in individuals with AGED triad + . These findings suggest that the AGED triad serves as a simplified and effective behavioral marker for accelerated progression to dementia.

Indexed as

ApathyDementiaExecutive FunctionGait Disorders, NeurologicAgedAged, 80 and overDepressionDisease ProgressionFemaleGeriatric AssessmentHumansIndependent LivingMaleApathyDementiaExecutive functionGait slownessVascular risk factors

Identifiers

PMID39384733
PMCPMC11979040

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.