Evidence map›Paper›PMID 39384699›Full record

ArticleCell biochemistry and biophysics2025

Harnessing Phytochemicals to Regulate Catalytic Residues of Alpha-Amylase and Alpha-Glucosidase in Type 2 Diabetes.

Sivaraman Dhanasekaran, Srikanth Jeyabalan, Abbas Alam Choudhury, Vijayarangan Devi Rajeswari, Gnanasambandan Ramanathan, Tamilanban Thamaraikani, Mahendran Sekar, Vetriselvan Subramaniyan, Wong Ling Shing

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Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Sivaraman DhanasekaranDepartment of Biotechnology, School of Energy Technology, Pandit Deendayal Energy University, Gandhinagar, Gujarat, India. sivaramand83@gmail.com.
Srikanth JeyabalanDepartment of Pharmacology, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Abbas Alam ChoudhuryVellore Institute of Technology, Vellore, Tamil Nadu, India.
Vijayarangan Devi RajeswariVellore Institute of Technology, Vellore, Tamil Nadu, India.
Gnanasambandan RamanathanVellore Institute of Technology, Vellore, Tamil Nadu, India.
Tamilanban ThamaraikaniDepartment of Pharmacology, Faculty of Medicine, MAHSA University, Jenjarom, Selangor, Malaysia.
Mahendran SekarMonash University, Subang Jaya, Selangor, Malaysia.
Vetriselvan SubramaniyanDepartment of Medical Sciences, School of Medical and Life Sciences, Sunway University, Jalan University, Selangor Darul Ehsan, Malaysia.
Wong Ling ShingINTI International University, Nilai, Negeri Sembilan, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes (T2D), also known as non-insulin-dependent diabetes mellitus, represents the prevailing manifestation of diabetes, encompassing a substantial majority of cases, ~90-95%. Plant-derived antidiabetic leads are being intensively explored due to their safety and effectiveness. The main objective of the present study is to evaluate the anti-diabetic potential of the traditional formulation Karisalai Karpam through in-vitro and in-silico investigations. The in-vitro and in-silico investigation of traditional polyherbal preparation Karisalai Karpam (KK) chooranam were performed to ascertain its inhibitory potential against α-amylase and α-glucosidase enzymes along with antioxidant (DPPH and ABTS) and phytochemical analysis. The results of enzyme inhibitory activity of KK witnessed highest activity against α-glucosidase enzyme with a percentage inhibition of 84.66 ± 2.50% (IC

Indexed as

alpha-Amylasesalpha-GlucosidasesDiabetes Mellitus, Type 2Glycoside Hydrolase InhibitorsHypoglycemic AgentsPhytochemicalsAntioxidantsCatalytic DomainHumansMolecular Docking Simulationalpha-Amylasesalpha-GlucosidasesAntioxidantsGlycoside Hydrolase InhibitorsHypoglycemic AgentsPhytochemicalsAlpha-amylaseAlpha-glucosidaseAnti-diabeticKarisalai KarpamMolecular dockingType 2 diabetes

Identifiers

PMID39384699

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.