Evidence map›Paper›PMID 39384430›Full record

ArticleLife science alliance2024

Naa80 is required for actin N-terminal acetylation and normal hearing in zebrafish.

Rasmus Ree, Sheng-Jia Lin, Lars Ole Sti Dahl, Kevin Huang, Cassidy Petree, Gaurav K Varshney, Thomas Arnesen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rasmus ReeDepartment of Biomedicine, University of Bergen, Bergen, Norway rasm@norceresearch.no.ORCID 0000-0002-8446-5301
Sheng-Jia LinGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.ORCID 0000-0002-7559-6529
Lars Ole Sti DahlDepartment of Biomedicine, University of Bergen, Bergen, Norway.ORCID 0009-0007-1221-6182
Kevin HuangGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Cassidy PetreeGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Gaurav K VarshneyGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA gaurav-varshney@omrf.org.ORCID 0000-0002-0429-1904
Thomas ArnesenDepartment of Biomedicine, University of Bergen, Bergen, Norway thomas.arnesen@uib.no.ORCID 0000-0002-3005-147X

Funding

European Research Council
6 · The paper itself

Abstract

Actin is a critical component of the eukaryotic cytoskeleton. In animals, actins undergo unique N-terminal processing by dedicated enzymes resulting in mature acidic and acetylated forms. The final step, N-terminal acetylation, is catalyzed by NAA80 in humans. N-terminal acetylation of actin is crucial for maintaining normal cytoskeletal dynamics and cell motility in human cell lines. However, the physiological impact of actin N-terminal acetylation remains to be fully understood. We developed a zebrafish

Indexed as

ActinsZebrafishZebrafish ProteinsAcetylationAcetyltransferasesAnimalsHearingHumansAcetyltransferasesActinsNAA80 protein, humanZebrafish Proteins

Identifiers

PMID39384430
PMCPMC11465159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.