Evidence map›Paper›PMID 39384429›Full record

ArticleLearning & memory (Cold Spring Harbor, N.Y.)2024

Reactivation-dependent transfer of fear memory between contexts requires M1 muscarinic receptor stimulation in dorsal hippocampus of male rats.

Karim H Abouelnaga, Andrew E Huff, Kristen H Jardine, Olivia S O'Neill, Boyer D Winters

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Learning & memory (Cold Spring Harbor, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Karim H AbouelnagaDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, N1G 2W1, Guelph ON, Canada abouelnk@uoguelph.ca.ORCID 0009-0007-7746-3459
Andrew E HuffDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, N1G 2W1, Guelph ON, Canada.ORCID 0000-0001-6876-9164
Kristen H JardineDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, N1G 2W1, Guelph ON, Canada.
Olivia S O'NeillDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, N1G 2W1, Guelph ON, Canada.
Boyer D WintersDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, N1G 2W1, Guelph ON, Canada.ORCID 0000-0003-3613-4441

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Memory updating is essential for integrating new information into existing representations. However, this process could become maladaptive in conditions like post-traumatic stress disorder (PTSD), when fear memories generalize to neutral contexts. Previously, we have shown that contextual fear memory malleability in rats requires activation of M1 muscarinic acetylcholine receptors in the dorsal hippocampus. Here, we investigated the involvement of this mechanism in the transfer of contextual fear memories to other contexts using a novel fear memory updating paradigm. Following brief reexposure to a previously fear conditioned context, male rats (

Indexed as

Conditioning, ClassicalFearHippocampusMuscarinic AntagonistsPirenzepineReceptor, Muscarinic M1AnimalsMaleMemoryRatsRats, Sprague-DawleyTransfer, PsychologyMuscarinic AntagonistsPirenzepineReceptor, Muscarinic M1

Identifiers

PMID39384429
PMCPMC11472233

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.