ArticleAJNR. American journal of neuroradiology2025
Evidence of Small Vessel Disease in Patients with Transient Global Amnesia Based on the Peak Width of Skeletonized Mean Diffusivity.
Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Altered structural connectivity in white matter lesion-induced mild cognitive impairment: a probabilistic fiber tracking and graph theory analysis.Frontiers in neural circuits · 2026Article
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3 authors.
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Abstract
background and purposeThe peak width of skeletonized mean diffusivity (PSMD) is a novel marker of small vessel disease. In this study, we aimed to investigate the presence of small vessel disease in patients with transient global amnesia (TGA) by using the PSMD. MATERIALS AND
methodsWe enrolled 75 patients newly diagnosed with TGA and included 65 age- and sex-matched healthy controls. DTI was performed by using a 3T MR imaging scanner. We measured the PSMD based on DTI by using the FSL program. This measure was compared between patients with TGA and healthy controls. Additionally, we conducted a correlation analysis to explore the relationship between PSMD and clinical factors.
resultsA significant difference in the PSMD between patients with TGA and healthy controls was observed. Patients with TGA exhibited higher a PSMD compared with healthy controls (2.297 ± 0.232 versus 2.188 ± 0.216 × 10
conclusionsThis finding underscores the feasibility of using PSMD as a marker for detecting small vessel diseases in patients with neurologic disorders. Furthermore, our study also implies the presence of small vessel disease may be present in patients with TGA.
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