Evidence map›Paper›PMID 39384180›Full record

ArticleJournal of medicinal chemistry2024

New LsrK Ligands as AI-2 Quorum Sensing Interfering Compounds against Biofilm Formation.

Giorgio Milli, Angelica Pellegrini, Roberta Listro, Marina Fasolini, Katiuscia Pagano, Laura Ragona, Giampiero Pietrocola, Pasquale Linciano, Simona Collina

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giorgio MilliDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, Pavia 27100, Italy.
Angelica PellegriniDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Viale Taramelli 3/b, Pavia 27100, Italy.
Roberta ListroDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, Pavia 27100, Italy.ORCID 0000-0001-7615-1284
Marina FasoliniNerviano Medical Sciences s.r.l., Viale Pasteur 10, Nerviano, Milano 20014, Italy.
Katiuscia PaganoNMR Laboratory, Istituto di Scienze e Tecnologie Chimiche "Giulio Natta", CNR, via Alfonso Corti, 12, Milano 20133, Italy.ORCID 0000-0002-0462-2056
Laura RagonaNMR Laboratory, Istituto di Scienze e Tecnologie Chimiche "Giulio Natta", CNR, via Alfonso Corti, 12, Milano 20133, Italy.ORCID 0000-0003-3893-7117
Giampiero PietrocolaDepartment of Molecular Medicine, Biochemistry Unit, University of Pavia, Viale Taramelli 3/b, Pavia 27100, Italy.ORCID 0000-0002-7069-8155
Pasquale LincianoDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, Pavia 27100, Italy.ORCID 0000-0003-0382-7479
Simona CollinaDepartment of Drug Sciences, University of Pavia, Viale Taramelli 12, Pavia 27100, Italy.ORCID 0000-0002-2954-7558

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance (AMR) represents a critical global health crisis. An innovative strategy to deal with AMR is to interfere with biofilm formation and bacterial quorum sensing (QS). In this study, newly designed autoinducer-2 (AI-2)-inspired compounds in targeting biofilm-associated infections were evaluated for their ability to inhibit biofilm formation in

Indexed as

Anti-Bacterial AgentsBiofilmsHomoserineLactonesMicrobial Sensitivity TestsPseudomonas aeruginosaQuorum SensingStaphylococcus aureusBacterial ProteinsEscherichia coli ProteinsLigandsPhosphotransferases (Alcohol Group Acceptor)Structure-Activity RelationshipAnti-Bacterial AgentsBacterial ProteinsEscherichia coli ProteinsHomoserineLactonesLigandsLsrK protein, E coliN-octanoylhomoserine lactonePhosphotransferases (Alcohol Group Acceptor)

Identifiers

PMID39384180
PMCPMC11513922

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.