ReviewCell reports. Medicine2024
Advances and challenges in neuroimaging-based pain biomarkers.
Review in Cell reports. Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- P300 Event-Related Potentials as Cognitive Biomarkers in Neurological and Neuropsychiatric Disorders: A Systematic Review.Revista de neurologia · 2026Pooled it
- Systematic Review of Methods for Individual Prediction of Postoperative Pain.Pain research & management · 2025Pooled it
- Electroencephalography research in neuropathic pain (Review).Molecular medicine reports · 2026Review
- Personalized Prediction of Acute and Chronic Postsurgical Pain - the role of Multidomain Biosignatures, Machine Learning-Based Integration, and Standardized Outcome Definitions.Current pain and headache reports · 2026Review
- Review
- Neuroimaging biomarkers for predicting acupuncture treatment response in chronic pain: a systematic review and meta-analysis protocol.BMJ open · 2026Article
- A predictive corticospinal model for pain perception.Cell reports. Medicine · 2026Article
- From Association to Prediction: Translational Barriers in Pain Biomarker Research.Journal of personalized medicine · 2026Article
- Development and validation of a clinical prediction model for acupuncture response in community-dwelling patients with chronic low back pain: a retrospective cohort study.BMC health services research · 2026Article
- fNIRS as a Biomarker for Preoperative Assessment: Correlating Brain Activity with Clinical Evaluation for Lumbar Disc Herniation.Bioengineering (Basel, Switzerland) · 2026Article
- Altered Structural Brain Connectivity in Postherpetic Neuralgia and its Association with Neuropathic Pain Severity: A Diffusion Tensor Imaging Study.Brain topography · 2026Article
- Review
- Unveiling state-specific neural dynamics in migraine with and without depressive symptom: a hidden Markov model and interpretable machine learning approach.The journal of headache and pain · 2026Article
- Structural and Functional Brain Alterations in Postherpetic Neuralgia: A Systematic Review and Voxel-Wise Coordinate-Based Meta-Analysis via the SDM-PSI Method.Journal of pain research · 2026Review
- Abnormal Brain Structure and Function in People with Shoulder Pain: A Systematic Review of Neuroimaging Studies.Journal of pain research · 2026Review
- Rethinking Pain Assessment: Subjective Scales, Biomarkers, and Multimodal Integration.Journal of pain research · 2026Review
- How to Undertake Personalized Assessments and Administer Cures for Pain.Journal of personalized medicine · 2025Article
- CDK5-Induced HCN2 Channel Dysfunction in the Prelimbic Cortex Drives Allodynia and Anxiety-Like Behaviors in Neuropathic Pain.Neuroscience bulletin · 2025Article
- Radiofrequency Ablation for Chronic Pain: Mechanistic Insights and Emerging Innovations.Cureus · 2025Review
- Genetic underpinnings and causal effects of brain structure and function on chronic pain intensity.Nature communications · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identifying neural biomarkers of pain has long been a central theme in pain neuroscience. Here, we review the state-of-the-art candidates for neural biomarkers of acute and chronic pain. We classify these potential neural biomarkers into five categories based on the nature of their target variables, including neural biomarkers of (1) within-individual perception, (2) between-individual sensitivity, and (3) discriminability for acute pain, as well as (4) assessment and (5) prospective neural biomarkers for chronic pain. For each category, we provide a synthesized review of candidate biomarkers developed using neuroimaging techniques including functional magnetic resonance imaging (fMRI), structural magnetic resonance imaging (sMRI), and electroencephalography (EEG). We also discuss the conceptual and practical challenges in developing neural biomarkers of pain. Addressing these challenges, optimal biomarkers of pain can be developed to deepen our understanding of how the brain represents pain and ultimately help alleviate patients' suffering and improve their well-being.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.