Evidence map›Paper›PMID 39383799›Full record

ArticleReproductive biomedicine online2024

Langerhans cell histiocytosis in children born after assisted reproductive technology.

Carrie L Williams, Kathryn J Bunch, Charles Stiller, Michael F G Murphy, Beverley J Botting, Melanie C Davies, Barbara Luke, Philip J Lupo, Alastair G Sutcliffe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive biomedicine online, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Treatment experience of patients with failedFrontiers in public health · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carrie L WilliamsUCL Great Ormond Street Institute of Child Health, London, UK.
Kathryn J BunchChildhood Cancer Research Group, Department of Paediatrics, University of Oxford, Oxford, UK.
Charles StillerNational Cancer Registration and Analysis Service, Public Health England, Oxford, UK.
Michael F G MurphyNuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK.
Beverley J BottingUCL Great Ormond Street Institute of Child Health, London, UK.
Melanie C DaviesReproductive Medicine Unit, University College London Hospitals, London, UK.
Barbara LukeDepartment of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, East Lansing, MI, USA.
Philip J LupoDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Alastair G SutcliffeUCL Great Ormond Street Institute of Child Health, London, UK. Electronic address: a.sutcliffe@ucl.ac.uk.

Funding

A US-UK Collaborative Study of the Health of Children Born From In Vitro Fertilization: From Conception Through Young AdulthoodR01HD112081 · NICHD · EMORY UNIVERSITY · PI BARBARA JOAN LUKE, Philip Lupo · 2023 to 2026
$2.3M
NICHD NIH HHS R01 HD112081
6 · The paper itself

Abstract

research questionAre children born after assisted reproductive technology (ART) at higher risk of developing Langerhans cell histiocytosis (LCH)?

designRecords of children born after ART recorded by the UK Human Fertilisation & Embryology Authority were linked to National Registry of Childhood Tumours records to determine the number of children developing LCH. Calculated person-years at risk were used in conjunction with the incidence of LCH in the general population to determine the expected number of cases if the cohort had the same incidence as the general population with similar age and sex, over the same calendar years. The standardized incidence ratio (SIR) was derived as the ratio of observed to expected cases. Exact 95% CI were calculated.

resultsIn total, 118,155 children born after ART contributed 796,633 person-years follow-up (average follow-up 6.74 years). Eight cases of LCH were identified, compared with 3.75 cases expected (SIR 2.135, 95% CI 0.92-4.21; P = 0.074). Significantly more cases were associated with intracytoplasmic sperm injection (ICSI) (SIR 4.02, 95% CI 1.31-9.39) and male factor infertility (SIR 5.41, 95% CI 1.47-13.84). Most cases of LCH had single-system disease (n = 6).

conclusionsThis study found that significantly more cases of LCH were identified in children born after ICSI and in children whose parents had male factor infertility. A non-significant excess of cases in children born after ART was identified. Absolute excess risk was small. Given the rarity of LCH and the small number of cases included in this large cohort, further studies into the risk of LCH in children born after ART are indicated.

Indexed as

Histiocytosis, Langerhans-CellReproductive Techniques, AssistedAdolescentChildChild, PreschoolFemaleHumansIncidenceInfantInfertility, MaleMaleRegistriesRisk FactorsSperm Injections, IntracytoplasmicUnited KingdomARTAssisted reproductive technologyICSIIntracytoplasmic sperm injectionLangerhans cell histiocytosis

Identifiers

PMID39383799
PMCPMC12258059

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.