Evidence map›Paper›PMID 39383522›Full record

ArticleBioinformatics (Oxford, England)2024

RTF: an R package for modelling time course data.

Eva Brombacher, Clemens Kreutz

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Eva BrombacherInstitute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center-University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0002-5488-0985
Clemens KreutzInstitute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center-University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0002-8796-5766

Funding

Deutsche ForschungsgemeinschaftGermany's Excellence Strategy CIBSS-EXC-2189-2100249960-390939984
6 · The paper itself

Abstract

summaryThe retarded transient function (RTF) approach serves as a complementary method to ordinary differential equations (ODEs) for modelling dynamics typically observed in cellular signalling processes. We introduce an R package that implements the RTF approach, originally implemented within the MATLAB-based Data2Dynamics modelling framework. This package facilitates the modelling of time and dose dependencies, and it includes the possibility of model reduction to minimize overfitting. It can be applied to experimental data or trajectories of ODE models to characterize their dynamics. Additionally, it can generate a low-dimensional representation based on the fitted RTF parameters of a set of time-resolved data, aiding in the identification of key targets of experimental perturbations. AVAILABILITY AND IMPLEMENTATION: The R package RTF is available at https://github.com/kreutz-lab/RTF.

Indexed as

SoftwareAlgorithmsComputational BiologyModels, BiologicalSignal Transduction

Identifiers

PMID39383522
PMCPMC11879456

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.