Evidence map›Paper›PMID 39383513›Full record

ArticleChannels (Austin, Tex.)2024

Binding kinetics of quaternary ammonium ions in Kcv potassium channels.

Tobias Korn, Ulf-Peter Hansen, Tobias Sebastian Gabriel, Oliver Rauh, Nils Drexler, Indra Schroeder

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Channels (Austin, Tex.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Similarity of the ion occupations of KChannels (Austin, Tex.) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tobias KornPlant Membrane Biophysics, Technische Universität Darmstadt, Darmstadt, Germany.
Ulf-Peter HansenDepartment of Structural Biology, Christian-Albrechts-University, Kiel, Germany.
Tobias Sebastian GabrielPlant Membrane Biophysics, Technische Universität Darmstadt, Darmstadt, Germany.
Oliver RauhPlant Membrane Biophysics, Technische Universität Darmstadt, Darmstadt, Germany.
Nils DrexlerPhysiology II, University Hospital Jena, Friedrich Schiller University, Jena, Germany.
Indra SchroederPlant Membrane Biophysics, Technische Universität Darmstadt, Darmstadt, Germany.ORCID 0000-0002-7875-983X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kcv channels from plant viruses represent the autonomous pore module of potassium channels, devoid of any regulatory domains. These small proteins show very reproducible single-channel behavior in planar lipid bilayers. Thus, they are an optimum system for the study of the biophysics of ion transport and gating. Structural models based on homology modeling have been used successfully, but experimental structural data are currently not available. Here we determine the size of the cytosolic pore entrance by studying the blocker kinetics. Blocker binding and dissociation rate constants ranging from 0.01 to 1000 ms

Indexed as

Potassium ChannelsQuaternary Ammonium CompoundsBinding SitesIon Channel GatingKineticsPotassium Channel BlockersViral ProteinsKcv potassium channel, Chlorella virusPotassium Channel BlockersPotassium ChannelsQuaternary Ammonium CompoundsViral Proteinsblockerdiffusion limitationFast blockplanar lipid bilayersingle-channel currentsviral potassium channel

Identifiers

PMID39383513
PMCPMC11575739

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.