Evidence map›Paper›PMID 39383246›Full record

ArticleScience translational medicine2024

An altered natural killer cell immunophenotype characterizes clinically severe pediatric RSV infection.

Roisin B Reilly, Saïsha K Ramdour, Mary E Fuhlbrigge, Luciana P Tavares, Steven J Staffa, Jocelyn M Booth, Nandini Krishnamoorthy, Bruce D Levy, Melody G Duvall

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Unconventional functions of natural killer cells in homeostasis and disease.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  2. Article
  3. Article
  4. Unique nasal cell states induced by common pediatric respiratory viruses.bioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Roisin B ReillyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-8628-4080
Saïsha K RamdourDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Mary E FuhlbriggeDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Luciana P TavaresDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-5319-0210
Steven J StaffaDivision of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-7588-7596
Jocelyn M BoothDivision of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0004-2283-9824
Nandini KrishnamoorthyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-1114-7118
Bruce D LevyDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-9515-5731
Melody G DuvallDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4173-3628

Funding

Pediatric Critical Care Scientist Development ProgramK12HD047349 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI HEATHER T. KEENAN, Kevin M Watt · 2004 to 2026
$17.0M
Specialized Pro-Resolving Mediators in AsthmaR01HL122531 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEVY, BRUCE D · 2014 to 2024
$4.7M
NK cell inflammation resolution circuits in pediatric RSV infectionR01HL171279 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Melody G. Duvall · 2024 to 2026
$2.1M
Specialized Pro-Resolving Mediator Regulation of NK Cells in Human RSV BronchiolitisK08HL145098 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DUVALL, MELODY G. · 2019 to 2022
$691k
NHLBI NIH HHS K08 HL145098NHLBI NIH HHS R01 HL122531NHLBI NIH HHS R01 HL171279NICHD NIH HHS K12 HD047349
6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) infects nearly all children by 2 years of age and is a leading cause of pediatric hospitalizations. A subset of children with RSV infection (RSV

Indexed as

ImmunophenotypingKiller Cells, NaturalRespiratory Syncytial Virus InfectionsAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensChildChild, PreschoolFemaleHumansImmunological SynapsesInfantLectins, C-TypeMaleNK Cell Lectin-Like Receptor Subfamily KSeverity of Illness IndexAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensKLRK1 protein, humanLectins, C-TypeNK Cell Lectin-Like Receptor Subfamily K

Identifiers

PMID39383246
PMCPMC12668293

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.