Evidence map›Paper›PMID 39383224›Full record

ArticleScience advances2024

DNA cytosine methylation suppresses meiotic recombination at the sex-determining region.

Tong Ge, Xiuqi Gui, Jia-Xi Xu, Wei Xia, Chao-Han Wang, Wenqiang Yang, Kaiyao Huang, Colum Walsh, James G Umen, Jörn Walter and 4 more

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Allele-specific methylation ofScience advances · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tong GeKey Laboratory of Epigenetic Regulation and Intervention, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0009-0005-4978-4234
Xiuqi GuiCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0009-0002-7680-477X
Jia-Xi XuKey Laboratory of Epigenetic Regulation and Intervention, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0009-0005-1461-8877
Wei XiaKey Laboratory of Epigenetic Regulation and Intervention, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0009-0000-0875-127X
Chao-Han WangKey Laboratory of Epigenetic Regulation and Intervention, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0009-0006-6312-7764
Wenqiang YangPhotosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China.ORCID 0000-0001-5600-4076
Kaiyao HuangKey Laboratory of Algal Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.ORCID 0000-0001-8669-1065
Colum WalshDepartment of Cell Biology, Institute for Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.ORCID 0000-0001-9921-7506
James G UmenDonald Danforth Plant Science Center, 975 N. Warson Rd, St. Louis, MO 63132, USA.ORCID 0000-0003-4094-9045
Jörn WalterDepartment of Genetics/Epigenetics, Saarland University, Saarbrücken 66123, Germany.ORCID 0000-0003-0563-7417
Ya-Rui DuKey Laboratory of Epigenetic Regulation and Intervention, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0009-0004-2094-9325
Hui ChenKey Laboratory of Epigenetic Regulation and Intervention, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0009-0003-2312-3142
Zhen ShaoCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-4934-4360
Guo-Liang XuKey Laboratory of Epigenetic Regulation and Intervention, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-3240-3141

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meiotic recombination between homologous chromosomes is vital for maximizing genetic variation among offspring. However, sex-determining regions are often rearranged and blocked from recombination. It remains unclear whether rearrangements or other mechanisms might be responsible for recombination suppression. Here, we uncover that the deficiency of the DNA cytosine methyltransferase DNMT1 in the green alga

Indexed as

CytosineDNA MethylationMeiosisRecombination, GeneticChlamydomonas reinhardtiiCytosine

Identifiers

PMID39383224
PMCPMC11463267

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.