ArticleScience advances2024
Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy.
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Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- PRMT5 encourages cell migration and metastasis of tongue squamous cell carcinoma through methylating ΔNp63α.Cell death and differentiation · 2026Article
- Case Report: transformation to SCLC from EGFR-mutated squamous cell lung carcinoma during osimertinib treatment.Frontiers in oncology · 2026Article
- Unraveling the characteristics of early esophageal neuroendocrine carcinoma using multi-model endoscopy: A retrospective study of serial cases.World journal of gastrointestinal oncology · 2025Article
- Multi-omics analysis reveals the crosstalk of epigenetic regulatory networks in cutaneous squamous cell carcinoma progression.Journal of translational medicine · 2025Article
- p63: A Master Regulator at the Crossroads Between Development, Senescence, Aging, and Cancer.Cells · 2025Review
- Intratumoral heterogeneity and potential treatment strategies in small cell lung cancer.Frontiers in oncology · 2025Review
- Advances in esophageal organoids: from construction to applications.Journal of tissue engineeringReview
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Authors and funding
24 authors.
Yongchun ZhangState Key Laboratory of Microbial Metabolism and Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0009-0009-9949-0604
Dimitris KaragiannisDepartment of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-4394-1076
Helu LiuColumbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-4527-4115
Mi LinColumbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Yinshan FangColumbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0001-9249-4498
Ming JiangCenter for Genetic Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310030, Zhejiang, China.
Xiao ChenDepartment of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0001-5059-8846
Supriya SureshColumbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Haidi HuangState Key Laboratory of Microbial Metabolism and Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0009-0005-1783-1016
Junjun SheDepartment of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.ORCID 0000-0001-5104-663X
Feiyu ShiDepartment of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.ORCID 0000-0001-5691-1362
Jiangying LiuState Key Laboratory of Microbial Metabolism and Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0009-0008-5022-093X
Dan LuoState Key Laboratory of Microbial Metabolism and Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0009-0006-1407-5320
J Carlos AngelDepartment of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0001-6531-7381
Guangtan LinColumbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Patrick YangDepartment of Internal Medicine, Westchester Medical Center/New York Medical College, Valhalla, NY 10595, USA.
Wael El-RifaiDepartment of Surgery and Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.ORCID 0000-0003-2101-6098
Alexander ZaikaDepartment of Surgery and Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.
Anthony E OroProgramin Epithelial Biology, Stanford University School of Medicine, Stanford 94305, CA, USA.ORCID 0000-0002-6261-138X
Kuancan LiuCentral Laboratory, Xiang'an Hospital, School of Medicine, Xiamen University, Xiamen 361102, Fujian, China.ORCID 0000-0002-2470-7479
Anil K RustgiDivision of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Timothy C WangDivision of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-2095-0121
Chao LuDepartment of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0003-0982-8122
Jianwen QueColumbia Center for Human Development, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-6540-6701
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MTransformed Esophageal Epithelial Cells and the Tumor MicroenvironmentP01CA098101 · NCI · UNIVERSITY OF PENNSYLVANIA · PI RUSTGI, ANIL K · 2003 to 2023
$31.7MSOX4-Mediated Transcription Program in Esophageal AdenocarcinomaP01CA268991 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI WAEL EL-RIFAI · 2022 to 2026
$9.2MThe Organoid and Cell Culture CoreP30DK132710 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Robert F. Schwabe · 2022 to 2026
$7.2MGastroesophageal junction stem cells as the origin of Barretts esophagus and cancerR01CA272901 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN, WANG, TIMOTHY CRAGIN · 2022 to 2025
$4.9MChromatin Dynamics During Epithelial CommitmentR01AR073170 · NIAMS · STANFORD UNIVERSITY · PI Anthony E Oro · 2019 to 2026
$4.4MCell Fate Regulation in Esophageal Progenitor CellsR01DK132251 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LU, CHAO, QUE, JIANWEN · 2022 to 2025
$2.3MEpigenetic Regulation of Head and Neck Cancer Immune EvasionR01DE031873 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Chao Lu · 2022 to 2026
$2.3MSignaling Mechanisms Promoting Barrett’s MetaplasiaR01DK120650 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2019 to 2022
$1.8MLeica Stellaris 8 Confocal MicroscopeS10OD032447 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2022 to 2022
$652kBD Biosciences InfluxS10OD020056 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2015 to 2015
$600kBLRD VA I01 BX002115BLRD VA IK6 BX006300NCI NIH HHS P01 CA098101NCI NIH HHS P01 CA268991NCI NIH HHS P30 CA013696NCI NIH HHS R01 CA272901NIAMS NIH HHS R01 AR073170NIDCR NIH HHS R01 DE031873NIDDK NIH HHS P30 DK132710NIDDK NIH HHS R01 DK120650NIDDK NIH HHS R01 DK132251NIH HHS S10 OD020056NIH HHS S10 OD032447
Abstract
While cell fate determination and maintenance are important in establishing and preserving tissue identity and function during development, aberrant cell fate transition leads to cancer cell heterogeneity and resistance to treatment. Here, we report an unexpected role for the transcription factor p63 (Trp63/TP63) in the fate choice of the squamous versus neuroendocrine lineage in esophageal development and malignancy. Deletion of
Indexed as
Cell TransdifferentiationEpigenesis, GeneticEsophageal NeoplasmsEsophagusAnimalsCarcinoma, NeuroendocrineCell Line, TumorEnhancer of Zeste Homolog 2 ProteinGene Expression Regulation, NeoplasticHumansMiceNeuroendocrine CellsTrans-ActivatorsTranscription FactorsTumor Suppressor ProteinsEnhancer of Zeste Homolog 2 ProteinTP63 protein, humanTrans-ActivatorsTranscription FactorsTrp63 protein, mouseTumor Suppressor Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.