Evidence map›Paper›PMID 39383041›Full record

ArticleCell reports2024

SIV-specific antibodies protect against inflammasome-driven encephalitis in untreated macaques.

Natalie J Castell, Celina M Abreu, Erin N Shirk, Suzanne E Queen, Joseph L Mankowski, Janice E Clements, Rebecca T Veenhuis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Natalie J CastellDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Celina M AbreuDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Erin N ShirkDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Suzanne E QueenDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Joseph L MankowskiDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Janice E ClementsDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Rebecca T VeenhuisDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: rterill1@jhmi.edu.

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
Viral Testing CoreU42OD013117 · OD · JOHNS HOPKINS UNIVERSITY · PI Lydia Hopper, JOSEPH L MANKOWSKI · 2017 to 2026
$10.9M
Project !: Differential contribution of resting CD4+ T cells and resident macrophages to viral rebound after antiretroviral treatment interruptionP01AI131306 · NIAID · JOHNS HOPKINS UNIVERSITY · PI MAC GABHANN, FEILIM C · 2017 to 2021
$8.5M
Training Veterinarians for Careers in Biomedical ResearchT32OD011089 · OD · JOHNS HOPKINS UNIVERSITY · PI JOSEPH L MANKOWSKI · 2012 to 2026
$6.7M
Defining sex-based differences in the replication-competent myeloid reservoir in virally suppressed people with HIV and SIV-infected ART-suppressed macaquesR01MH127981 · NIMH · JOHNS HOPKINS UNIVERSITY · PI VEENHUIS, REBECCA TERILLI · 2021 to 2025
$3.7M
Inflammasome activation in an SIV-ART model of chronic drug abuseR01DA050529 · NIDA · JOHNS HOPKINS UNIVERSITY · PI VEENHUIS, REBECCA TERILLI · 2019 to 2023
$3.5M
Viral Host Interactions in SIV Cardiac DysfunctionR01HL078479 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MANKOWSKI, JOSEPH L · 2004 to 2008
$2.7M
Mechanisms of HIV-Induced PNS Disease: The SIV Macaque ModelR01NS055651 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MANKOWSKI, JOSEPH L · 2006 to 2009
$2.5M
NHLBI NIH HHS R01 HL078479NIAID NIH HHS P01 AI131306NIAID NIH HHS P30 AI094189NIDA NIH HHS R01 DA050529NIH HHS T32 OD011089NIH HHS U42 OD013117NIMH NIH HHS R01 MH127981NINDS NIH HHS R01 NS055651
6 · The paper itself

Abstract

Viral encephalitis is a growing public health threat with limited diagnostic and treatment options. Simian immunodeficiency virus (SIV)-infected macaques are an established model for human immunodeficiency virus (HIV), and approximately 60% of untreated pigtail macaques rapidly progress to characteristic SIV encephalitis (SIVE). The immune responses of SIV-infected macaques are investigated in plasma, cerebrospinal fluid (CSF), and brain tissue to determine correlates with SIVE pathology. Macaques with SIVE show myeloid-dominant brain lesions with inflammasome activation in infected and bystander cells, as assessed by interleukin (IL)-1β, IL-18, and apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC), and elevations in monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1α, and tumor necrosis factor alpha (TNF-α). SIV-specific immunoglobulin (Ig)G in plasma and CSF is predictive of SIVE as early as 21 days post-inoculation; animals with SIVE continue to show negligible seroconversion 3 months after infection. This dichotomy in immune responses, wherein some macaques fail to initiate robust IgG responses and subsequently develop SIVE, provides insight into the pathogenesis and heterogeneous outcomes in viral encephalitis.

Indexed as

InflammasomesSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAnimalsAntibodies, ViralBrainEncephalitis, ViralImmunoglobulin GMacacaMacaca nemestrinaAntibodies, ViralImmunoglobulin GInflammasomesASCCP: ImmunologyIgGIL-18IL-1βinflammasomeseroconversionsimian immunodeficiency virusviral encephalitis

Identifiers

PMID39383041
PMCPMC11552693

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.