Evidence map›Paper›PMID 39382982›Full record

ArticleJournal of neurophysiology2024

Altered control of breathing in a rat model of allergic lower airway inflammation.

Barbara J Morgan, Ruolin Song, Ivy McDermott, Jacqueline A Brinkman, Kelsey Holbert, Angie T Oler, Amy S Dresen, Nathan Sandbo, Ksenija Bernau, Mihaela Teodorescu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Barbara J MorganDepartment of Orthopedics and Rehabilitation, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States.ORCID 0000-0003-2082-3963
Ruolin SongDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States.ORCID 0009-0001-5274-7910
Ivy McDermottDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States.
Jacqueline A BrinkmanDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States.
Kelsey HolbertDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States.
Angie T OlerDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States.
Amy S DresenDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States.
Nathan SandboDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States.
Ksenija BernauDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States.ORCID 0000-0002-3924-2969
Mihaela TeodorescuDepartment of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States.ORCID 0000-0002-4490-6926

Funding

Elucidating tensin1-associated signals that promote fibronectin matrix assembly and lung fibrosisR01HL146402 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI SANDBO, NATHAN K · 2019 to 2023
$1.7M
Optimization and development of extracellular matrix-targeting probes for PET-based assessment of lung fibrosis disease activityK01HL171464 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Ksenija Bernau · 2024 to 2026
$391k
NHLBI NIH HHS K01 HL171464NHLBI NIH HHS R01 HL146402U.S. Department of Veterans Affairs (VA) 1l01BX002880-01A2UW | School of Medicine and Public Health, University of Wisconsin-Madison (UWSMPH)
6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) is highly prevalent in patients with asthma. Asthma, dose-dependently to its duration, promotes incident OSA, suggesting that asthma plays a role in OSA pathogenesis. We hypothesized that asthma-related inflammation alters breathing control mechanisms, specifically the carotid chemoreflex. Accordingly, we measured hypoxic ventilatory responses (HVR) in awake, unrestrained, ovalbumin (OVA)-sensitized Brown Norway rats and compared them with responses in sham-sensitized (SALINE) controls. To differentiate the role of allergic inflammation from bronchoconstriction, we repeated hypoxic ventilatory response (HVR) after administration of formoterol, a long-acting bronchodilator. Blood and bronchoalveolar lavage (BAL) fluid were collected for quantification of inflammatory cytokines. The rise in ventilatory equivalent for O

Indexed as

AsthmaHypoxiaOvalbuminAnimalsBronchoalveolar Lavage FluidBronchodilator AgentsCytokinesDisease Models, AnimalFormoterol FumarateInflammationMaleRatsRats, Inbred BNRespirationBronchodilator AgentsCytokinesFormoterol FumarateOvalbuminasthmaBrown Norway ratcarotid body chemoreceptorhypoxic ventilatory responseobstructive sleep apnea

Identifiers

PMID39382982
PMCPMC11573259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.