Evidence map›Paper›PMID 39382794›Full record

ArticleJapanese journal of radiology2025

Sinonasal adenoid cystic carcinoma: preoperative apparent diffusion coefficient histogram analysis in prediction of prognosis and Ki-67 proliferation status.

Jingfeng Cheng, Quan Liu, Yuzhe Wang, Yang Zhan, Yin Wang, Dandan Shen, Yue Geng, Linying Guo, Zuohua Tang

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Article in Japanese journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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9 authors.

Jingfeng Cheng *Department of Radiology, Eye & ENT Hospital of Fudan University, Shanghai Medical School, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Quan Liu *Department of Otolaryngology, Eye & ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Yuzhe Wang *Department of Radiology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Yang ZhanDepartment of Radiology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
Yin WangDepartment of Radiology, Eye & ENT Hospital of Fudan University, Shanghai Medical School, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Dandan ShenDepartment of Radiology, Eye & ENT Hospital of Fudan University, Shanghai Medical School, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Yue GengDepartment of Radiology, Eye & ENT Hospital of Fudan University, Shanghai Medical School, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Linying GuoDepartment of Radiology, Eye & ENT Hospital of Fudan University, Shanghai Medical School, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Zuohua TangDepartment of Radiology, Eye & ENT Hospital of Fudan University, Shanghai Medical School, Fudan University, 83 Fenyang Road, Shanghai, 200031, China. tzh518sunny@163.com.

Funding

"Excellent doctor-Excellent Clinical Researcher" Project of Eye and ENT Hospital, Fudan University SYA202007"Keqing-Deji" science and technology innovation project of Fudan University SCH6222206A/022
6 · The paper itself

Abstract

purposeTo investigate the value of preoperative apparent diffusion coefficient (ADC) histogram analysis in predicting the prognosis of patients with sinonasal adenoid cystic carcinoma (ACC) and the correlation between ADC histogram parameters and Ki-67 labeling index (LI). MATERIALS AND

methodsThe study enrolled 66 patients with sinonasal ACC who were surgically resected and confirmed by histopathology. The disease-free survival (DFS) was evaluated with clinical-pathologic and radiologic characteristics using the Cox proportion hazard model. Spearman correlation analysis was used to evaluate the correlation between ADC histogram parameters and Ki-67 LI. The predictive performance of ADC histogram parameters for Ki-67 LI was assessed using the receiver operating characteristic (ROC) curve.

resultsMultivariable analysis showed Ki-67 LI (hazard ratio: 9.279; 95% confidence interval 1.099-78.338; P = 0.041) and ADCskewness (hazard ratio: 5.942; 95% confidence interval 1.832-19.268; P = 0.003) were significant independent predictors of DFS. The combination of these two variables achieved the predictive ability with a C-index of 0.717 (95% confidence interval 0.607-0.826). ADCmean and all ADC percentiles (10th, 50th, and 90th) significantly and inversely correlated with Ki-67 LI of ACC (Correlation coefficients = - 0.574 to - 0.591, Ps < 0.001). Among the ADC histogram parameters, the ADC50th showed superior performance for the differentiation of the high from low Ki-67 LI groups with an area under the curve (AUC) of 0.834 and an accuracy of 80.30%.

conclusionADC histogram analysis had predictive value for DFS and Ki-67 LI, which may be a valuable biomarker for prognosis and proliferation status for ACC in clinical practice.

Indexed as

Carcinoma, Adenoid CysticDiffusion Magnetic Resonance ImagingKi-67 AntigenParanasal Sinus NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsPrognosisRetrospective StudiesKi-67 AntigenAdenoid cystic carcinomaApparent diffusion coefficientHistogram analysisMagnetic resonance imagingSinonasal

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PMID39382794

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