Evidence map›Paper›PMID 39382780›Full record

ArticlePediatric surgery international2024

Does serum albumin at the onset of necrotisıng enterocolitis predict severe disease in preterm infants?

Gökçe Çıplak, Fatma Nur Sarı, Elif Emel Erten, Müjdem Nur Azılı, Süleyman Arif Bostancı, Cüneyt Tayman, Evrim Alyamaç Dizdar, Emrah Şenel

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Article in Pediatric surgery international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Gökçe ÇıplakDepartment of Neonatology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkey. gokchech@gmail.com.
Fatma Nur SarıDepartment of Neonatology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkey.
Elif Emel ErtenDepartment of Pediatric Surgery, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkey.
Müjdem Nur AzılıFaculty of Medicine, Department of Pediatric Surgery, Ankara Yıldırım Beyazıt University, Ankara, Turkey.
Süleyman Arif BostancıDepartment of Pediatric Surgery, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkey.
Cüneyt TaymanDepartment of Neonatology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkey.
Evrim Alyamaç DizdarDepartment of Neonatology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkey.
Emrah ŞenelFaculty of Medicine, Department of Pediatric Surgery, Ankara Yıldırım Beyazıt University, Ankara, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate whether laboratory markers obtained at the onset of necrotising enterocolitis (NEC) predict the severity of the disease in preterm infants.

methodsProspective cohort study conducted in a tertiary referance hospital. A total of 88 preterm infants were included in the study. Of those, 60 infants had the diagnosis of severe NEC, while the remaining 28 infants constituted the non-severe NEC group. Severe NEC was defined as surgical NEC or NEC-related mortality. Infants with and without severe NEC were compared in terms of demographic, clinical and laboratory characteristics.

resultsAt the onset of disease, infants with severe NEC noted to have lower platelet count and serum ALB levels (p = 0.011, p = 0.004; respectively), whereas higher CRP, and serum lactate levels (p = 0.009, p = 0.008; respectively). Multiple binary logistic regression analyses showed that CRP (1.03(1.01-1.05), p = 0.024) and serum albumin level (0.16(0.04-0.64), p = 0.010) were statistically significant independent risk factors for severe NEC. The optimal cut-off value for the serum ALB level was found to be 23 g/L with 52% sensitivity (95%CI: 37-68%) and 84% specificity (95%CI: 60-97%) (AUC 0.727; p = 0.002).

conclusionSerum ALB level at NEC onset might be a reliable biomarker for severe disease in preterm infants.

Indexed as

BiomarkersEnterocolitis, NecrotizingInfant, PrematureSerum AlbuminSeverity of Illness IndexFemaleHumansInfant, NewbornInfant, Premature, DiseasesMalePredictive Value of TestsProspective StudiesRisk FactorsBiomarkersSerum AlbuminBiomarkersPreterm infantsSerum albuminSeverity of NEC

Identifiers

PMID39382780

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