Evidence map›Paper›PMID 39382763›Full record

ArticleInternational journal of implant dentistry2024

Enhanced alveolar ridge preservation with hyaluronic acid-enriched allografts: a comparative study of granular allografts with and without hyaluronic acid addition.

Frank R Kloss, Thomas Kau, Diana Heimes, Peer W Kämmerer, Anita Kloss-Brandstätter

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of implant dentistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07031895 (Evaluation of the Efficacy of Xenograft Containing Hyaluronic Acid in Socket Preservation Procedure Radiologically and Histologically), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07031895 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluation of the Efficacy of Xenograft Containing Hyaluronic Acid in Socket Preservation Procedure Radiologically and Histologically: A Prospective Randomized Controlled Clinical Study

TypeinterventionalSponsorTC Erciyes UniversityRan2025 to 2026Enrolled60ConditionsSocket PreservationArmsa bovine-derived graft/xenograft enriched with hyaluronic acid, a standart bovine-derived graft/xenograft
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Frank R KlossPrivate Clinic for Oral, Maxillofacial and Plastic Facial Surgery, Kärntnerstraße 62, Lienz, 9900, Austria.
Thomas KauDepartment of Radiology, Landeskrankenhaus Villach, Nikolaigasse 43, Villach, 9500, Austria.
Diana HeimesDepartment of Oral and Maxillofacial Surgery/Plastic Surgery, University of Mainz, Augustusplatz 2, Mainz, 55131, Germany.
Peer W KämmererDepartment of Oral and Maxillofacial Surgery/Plastic Surgery, University of Mainz, Augustusplatz 2, Mainz, 55131, Germany.
Anita Kloss-BrandstätterDepartment of Engineering & IT, Carinthia University of Applied Sciences, Europastraße 4, Villach, 9524, Austria. a.kloss-brandstaetter@fh-kaernten.at.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRidge preservation is essential to restore alveolar ridge volume and to enhance esthetic and functional outcomes for dental implants. The addition of hyaluronic acid to allogeneic bone substitute materials might enhance these outcomes. This clinical study evaluated the efficacy of ridge preservation after tooth extraction using granular allografts with and without hyaluronic acid addition.

methodsIn this retrospective study, 40 patients with compromised extraction sockets were enrolled. Among them, 19 received particulate allogeneic bone substitutes (Allo), 21 received allogeneic bone substitutes with hyaluronic acid (AlloHya). Vertical and horizontal graft stability, graft shrinkage rate, and bone mineral density were assessed using radiographic measurements on CBCT scans conducted before tooth extraction, directly after ridge preservation and after four months. Patients were followed up 12 months post-implantation.

resultsVertical height loss after 4 months was significantly greater in the Allo group (-0.82 ± 0.95 mm) compared to the AlloHya group (-0.19 ± 0.51 mm; p = 0.011). Graft shrinkage rate was 16.9 ± 11.5% (Allo) and 10.3 ± 7.7% (AlloHya) (p = 0.038). After four months, average bone density was significantly higher in the AlloHya compared to the Allo group (p = 0.004). Nearly all implants (39 out of 40) were classified as "Success" according to the ICOI scheme, with no differences in implant quality between the two study groups.

conclusionsImproved graft stability, reduced resorption, and increased bone density were observed in hyaluronic acid-enriched allografts compared to pure allografts. Adding hyaluronic acid to allogeneic bone grafts significantly enhanced outcomes in ridge preservation.

Indexed as

AllograftsAlveolar Ridge AugmentationHyaluronic AcidAdultAgedAlveolar Bone LossBone DensityBone SubstitutesBone TransplantationFemaleHumansMaleMiddle AgedRetrospective StudiesTooth ExtractionTooth SocketBone SubstitutesHyaluronic AcidAllogeneic bone materialDental implantsExtraction socketsHyaluronic acidmaxgraft®Regenerative dentistrySocket preservation

Identifiers

PMID39382763
PMCPMC11465134

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.