Evidence map›Paper›PMID 39382678›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2025

Fritillaria steroidal alkaloids and their multi-target therapeutic mechanisms: insights from network pharmacology.

Pankaj Kumar, Vinay Kumar, Shagun Sharma, Rohit Sharma, Ashish R Warghat

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Plants (Basel, Switzerland) · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pankaj Kumar *Department of Biotechnology, Dr Y.S, Parmar University of Horticulture and Forestry, Solan, Himachal Pradesh, India. pksharmabiotech@gmail.com.
Vinay Kumar *Department of Biotechnology, Dr Y.S, Parmar University of Horticulture and Forestry, Solan, Himachal Pradesh, India.
Shagun Sharma *Department of Biotechnology, Dr Y.S, Parmar University of Horticulture and Forestry, Solan, Himachal Pradesh, India.
Rohit SharmaDepartment of Forest Products, Dr Y.S, Parmar University of Horticulture and Forestry, Solan, Himachal Pradesh, India.
Ashish R WarghatCSIR-Institute of Himalayan Bioresource Technology, Palampur, 176061, Himachal Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medicinal Fritillaria herbs, known for their rich content of steroidal alkaloids, have emerged as promising candidates in the treatment of chronic diseases due to their diverse pharmacological properties. Leveraging advancements in network pharmacology and molecular docking, this study explores the multi-target mechanisms through which these alkaloids exert therapeutic effects. The integration of bioinformatics, systems biology, and pharmacology in drug discovery has provided insights into the molecular interactions and pathways influenced by Fritillaria steroidal alkaloids. This review synthesizes comprehensive literature from 1985 to 2024, revealing the potential of these compounds in addressing respiratory diseases, inflammation, and cancer. The integration of traditional Chinese medicine (TCM) with modern pharmacological techniques underscores the relevance of these compounds in next-generation drug discovery. While initial findings are promising, further empirical validation is necessary to fully harness the therapeutic potential of Fritillaria steroidal alkaloids.

Indexed as

AlkaloidsDrugs, Chinese HerbalFritillariaSteroidsAnimalsDrug DiscoveryHumansMedicine, Chinese TraditionalMolecular Docking SimulationNetwork PharmacologyAlkaloidsDrugs, Chinese HerbalSteroidsAlkaloidsFritillariaLiliaceaeMolecular dockingNetwork pharmacologySteroidal alkaloids

Identifiers

PMID39382678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.