Evidence map›Paper›PMID 39382454›Full record

Trial reportEpilepsia2024

Establishing the minimum clinically important difference of the Quality of Life in Childhood Epilepsy Questionnaire.

Mariela Leda, Klajdi Puka, Karen Bax, Joel J Gagnier, Karina Tassiopoulos, Kathy Nixon Speechley

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Epilepsia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mariela LedaDepartment of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.ORCID https://orcid.org/0009-0002-5024-9464
Klajdi PukaDepartment of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
Karen BaxChild Health Research Institute, Lawson Health Research Institute, London, Ontario, Canada.
Joel J GagnierDepartment of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
Karina TassiopoulosDepartment of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-2820-3884
Kathy Nixon SpeechleyDepartment of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.ORCID https://orcid.org/0000-0003-0986-5476

Funding

CIHR PJT-159504
6 · The paper itself

Abstract

objectiveTo estimate the minimum clinically important difference (MCID) for the parent-reported 55-item Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55) and its shortened 16-item version, QOLCE-16.

methodsData came from 74 children with epilepsy (CWE) (ages 4-10, mean age = 8 [SD = 1.8]) enrolled in the Making Mindfulness Matter in Epilepsy (M3-E) trial, a pilot, parallel randomized-controlled trial of a mindfulness-based intervention. Both anchor-based and distribution-based methods were used to estimate MCID values for the QOLCE-55 and QOLCE-16. For the anchor-based approach, the Patient Centered Global Ratings of Change (PCGRC) scale and linear regression analysis were used to estimate the MCID. For the distribution-based approach, .5 SD of the health-related quality of life (HRQOL) change score distribution was used to estimate the MCID.

resultsFor the QOLCE-55, the MCID obtained using an anchor-based approach was 10 points and using a distribution-based method was 6 points. For the QOLCE-16, the MCID obtained using an anchor-based method was 13 points and using a distribution-based method was 7 points. SIGNIFICANCE: This is the first study to estimate MCID values for the QOLCE-55 and the QOLCE-16. It has been well documented that CWE are at risk of experiencing psychological, behavioral, and cognitive impairments, which can negatively impact their HRQOL. Reporting MCID values for the QOLCE-55 and QOLCE-16 is important in determining whether changes in HRQOL observed are meaningful to CWE themselves, as a key factor in shaping the nature of epilepsy care delivered.

Indexed as

EpilepsyQuality of LifeChildChild, PreschoolFemaleHumansMaleMindfulnessMinimal Clinically Important DifferencePilot ProjectsSurveys and Questionnaireschildrenepilepsyhealth‐related quality of lifeminimum clinically important differenceQuality of Life in Childhood Epilepsy Questionnaire (QOLCE‐55) (QOLCE‐16)

Identifiers

PMID39382454
PMCPMC11647425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.