Evidence map›Paper›PMID 39382276›Full record

ArticleAntimicrobial agents and chemotherapy2024

Synthesis of a dehydrodieugenol B derivative as a lead compound for visceral leishmaniasis-mechanism of action and

Maiara Amaral, Maiara M Romanelli, Hannah Asiki, Joana Bicker, Daniela P Lage, Camila S Freitas, Noemi N Taniwaki, Joao Henrique G Lago, Eduardo A F Coelho, Amílcar Falcão and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maiara AmaralLaboratory of Physiopathology, Instituto Butantan, São Paulo, Brazil.
Maiara M RomanelliInstituto de Medicina Tropical, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
Hannah AsikiDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, United Kingdom.
Joana BickerLaboratory of Pharmacology and Pharmaceutical Care, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Daniela P LageLaboratório de Pesquisa do Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Camila S FreitasLaboratório de Pesquisa do Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Noemi N TaniwakiLaboratory of Electron Microscopy, Instituto Adolfo Lutz, São Paulo, Brazil.
Joao Henrique G LagoCenter for Natural and Human Sciences, Federal University of ABC, Santo Andre, Brazil.
Eduardo A F CoelhoLaboratório de Pesquisa do Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Amílcar FalcãoLaboratory of Pharmacology and Pharmaceutical Care, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
Ana FortunaLaboratory of Pharmacology and Pharmaceutical Care, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.ORCID 0000-0001-6981-6639
Edward A AndersonDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-4149-0494
Andre G TemponeInstituto de Medicina Tropical, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0003-2559-7344

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) 001Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2021/04464-8
6 · The paper itself

Abstract

Leishmaniasis is a parasitic neglected tropical disease, affecting 12 million people. Available treatments present several limitations, with an increasing number of resistance cases. In the search for new chemotherapies, the natural product dehydrodieugenol B was used as a scaffold for the synthesis of a series of derivatives, resulting in the discovery of the promising analog [4-(4-(5-allyl-3-methoxy-2-((4-methoxybenzyl)oxy)phenoxy)-3-methoxybenzyl)morpholine,

Indexed as

Antiprotozoal AgentsLeishmania infantumLeishmaniasis, VisceralReactive Oxygen SpeciesAnimalsEugenolFemaleHumansMembrane Potential, MitochondrialMiceMice, Inbred BALB CRatsAntiprotozoal AgentsEugenolReactive Oxygen SpeciesLeishmaniamechanism of actionnatural product derivativepharmacokinetic

Identifiers

PMID39382276
PMCPMC11539218

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.