ArticleJournal of the American Geriatrics Society2025
Peak expiratory flow predicts motoric cognitive risk syndrome: A cohort study.
Article in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Age-friendly environments and incident motoric cognitive risk syndrome in older adults: A prospective cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Peak Expiratory Flow and Its Trajectories Associated With Frailty in Older Adults: A Prospective Cohort Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- From Dual Decline to Clinical Consequences: Mechanistic Pathways and Health Outcomes of Motoric Cognitive Risk Syndrome.Aging and disease · 2025Review
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Authors and funding
3 authors.
Funding
Abstract
backgroundPoor respiratory function, including low peak expiratory flow (PEF), is a risk factor for dementia. Motoric cognitive risk syndrome (MCR) is a predementia syndrome characterized by slow gait and subjective cognitive complaints. However, the association between PEF and MCR remains unclear. This study examined the cross-sectional and longitudinal association between PEF and MCR.
methodsThe National Health and Aging Trends Study (NHATS), which is a nationally representative cohort of adults ≥65 years of age in the United States, was analyzed from 2011 to 2017. Logistic regression and discrete-time proportional hazards models tested the association of PEF standardized residuals (SR) at baseline with prevalent and incident MCR, respectively. The models adjusted for multiple sociodemographic and health-related covariates.
resultsAmong 5328 participants (57% women) included at baseline, lower PEF SR was associated with higher prevalence of MCR. Compared with the ≥80 PEF SR percentile group, the <30 and 30-50 percentile groups had significantly higher odds of prevalent MCR (OR 3.04 [95% CI 1.85, 5.01]; OR 2.06 [95% CI 1.19, 3.54], respectively). Over six years of follow-up, lower PEF SR was also associated with higher incidence of MCR. Compared with the ≥80 PEF SR percentile group, the <30 and 30-50 percentile groups had significantly higher risk of incident MCR (HR 1.81 [95% CI 1.24, 2.66]; HR 1.55 [95% CI 1.02, 2.34], respectively).
conclusionsLower PEF was associated with higher prevalence and incidence of MCR. Poor respiratory function should be further investigated as a potentially modifiable risk factor for MCR and cognitive decline.
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