ArticleDevelopment (Cambridge, England)2024
A role for organ level dynamics in morphogenesis of the C. elegans hermaphrodite distal tip cell.
Article in Development (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Non-autonomy of age-related morphological changes in the C. elegans germline stem cell niche.Development (Cambridge, England) · 2025Article
- Non-autonomy of age-related morphological changes in thebioRxiv : the preprint server for biology · 2025Article
- MIG-21 interacts with Wnt and Netrin signaling in gonad migration in C. elegans.PLoS genetics · 2025Article
- MIG-21 is a novel regulator of Wnt and Netrin signaling in gonad migration identified from published scRNA-seq data and functionally validated inbioRxiv : the preprint server for biology · 2025Article
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3 authors.
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Abstract
The morphology of cells in vivo can arise from a variety of mechanisms. In the Caenorhabditis elegans hermaphrodite gonad, the distal tip cell (DTC) elaborates into a complex plexus over a relatively short developmental time period, but the mechanisms underlying this change in cell morphology are not well defined. We correlated the time of DTC elaboration with the L4-to-adult molt, but ruled out a relevant heterochronic pathway as a cue for DTC elaboration. Instead, we found that the timing of gonad elongation and aspects of underlying germline flux influence DTC elaboration. We propose a 'hitch and tow' aspect of organ-level dynamics that contributes to cellular morphogenesis, whereby germline flux drags the flexible DTC cell cortex away from its stationary cell body. More broadly, we speculate that this mechanism may contribute to cell shape changes in other contexts with implications for development and disease.
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