Evidence map›Paper›PMID 39382025›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2024

Overexpression of CPT1A disrupts the maintenance and regenerative function of muscle stem cells.

Jiamin Qiu, Feng Yue, Kun Ho Kim, Xiyue Chen, Mennatallah A Khedr, Jingjuan Chen, Lijie Gu, Junxiao Ren, Christina R Ferreira, Jessica Ellis and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiamin QiuDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0003-1490-5858
Feng YueDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0002-5856-3506
Kun Ho KimDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0002-5047-703X
Xiyue ChenDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID 0009-0007-0598-6189
Mennatallah A KhedrDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID 0009-0003-2449-3575
Jingjuan ChenDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID 0009-0002-7136-4090
Lijie GuDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0003-2518-9519
Junxiao RenDepartment of Animal Sciences, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-4203-1289
Christina R FerreiraPurdue Metabolite Profiling Facility, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0003-3988-6454
Jessica EllisDepartment of Physiology and East Carolina Diabetes and Obesity Institute, Brody School of Medicine at East Carolina University, Greenville, North Carolina, USA.ORCID 0000-0003-3803-8461
Shihuan KuangDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0001-9180-3180

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
Determining the Biological Effects of Mitochondrial Acyl ToxicityR01DK125812 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ELLIS, JESSICA M · 2020 to 2025
$2.3M
Immunomyoblasts in muscle regenerationR01AR078695 · NIAMS · PURDUE UNIVERSITY · PI KUANG, SHIHUAN · 2021 to 2025
$2.2M
Metabolic regulation of muscle satellite cell homeostasisR01DK132819 · NIDDK · PURDUE UNIVERSITY · PI Shihuan Kuang · 2023 to 2026
$2.0M
Targeting PTEN to ameliorate muscular dystrophy in a mouse modelR01AR079235 · NIAMS · PURDUE UNIVERSITY · PI KUANG, SHIHUAN · 2022 to 2025
$1.3M
HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR078695HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) R01AR079235HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK132819NCI NIH HHS P30 CA023168NIAMS NIH HHS R01 AR078695NIAMS NIH HHS R01 AR079235NIDDK NIH HHS R01 DK125812NIDDK NIH HHS R01 DK132819Purdue University Center for Cancer Research P30CA023168
6 · The paper itself

Abstract

The skeletal muscle satellite cells (SCs) mediate regeneration of myofibers upon injury. As they switch from maintenance (quiescence) to regeneration, their relative reliance on glucose and fatty acid metabolism alters. To explore the contribution of mitochondrial fatty acid oxidation (FAO) pathway to SCs and myogenesis, we examined the role of carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of FAO. CPT1A is highly expressed in quiescent SCs (QSCs) compared with activated and proliferating SCs, and its expression level decreases during myogenic differentiation. Myod1

Indexed as

Carnitine O-PalmitoyltransferaseMuscle DevelopmentMuscle, SkeletalSatellite Cells, Skeletal MuscleAnimalsCell DifferentiationCell ProliferationFatty AcidsMaleMiceMice, Inbred C57BLRegenerationCarnitine O-PalmitoyltransferaseCPT1B protein, mouseFatty Acidsacyl‐carnitineCPT1Afatty acid oxidationmuscle regenerationsatellite cell

Identifiers

PMID39382025
PMCPMC11486317

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.