Evidence map›Paper›PMID 39381901›Full record

ArticleChembiochem : a European journal of chemical biology2024

Mono-Palmitoyl-N-Alkylurea Ligands as Specific Activators of Human Toll-Like Receptor 2/6 Heterodimer.

Marjolein M E Isendoorn, Giulia Castello, Çağla Koç, Nico Meeuwenoord, Jeroen D C Codée, Ferry Ossendorp, Dmitri V Filippov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marjolein M E IsendoornLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden The, Netherlands.
Giulia CastelloDepartment of Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden The, Netherlands.ORCID 0000-0002-5647-178X
Çağla KoçLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden The, Netherlands.
Nico MeeuwenoordLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden The, Netherlands.
Jeroen D C CodéeLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden The, Netherlands.
Ferry OssendorpDepartment of Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden The, Netherlands.ORCID 0000-0001-9730-7954
Dmitri V FilippovLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC, Leiden The, Netherlands.ORCID 0000-0002-6978-7425

Funding

ICI ICI00031
6 · The paper itself

Abstract

Ligands for Toll-like-receptor 2 (TLR2) have demonstrated significant potential as immune-stimulating components in synthetic vaccines. Activation of TLR2 relies on the formation of dimeric complexes with either TLR1 or TLR6 and the nature of these dimers can impact therapeutic outcomes. The lipopeptide-based TLR2 ligands Pam

Indexed as

Toll-Like Receptor 2Toll-Like Receptor 6UreaHumansLigandsLipopeptidesProtein MultimerizationLigandsLipopeptidesTLR2 protein, humanTLR6 protein, humanToll-Like Receptor 2Toll-Like Receptor 6UreaAmino acidsImmunostimulantsLipopeptidesMini-UpamSelective TLR2/6 ligandsSolid phase synthesis

Identifiers

PMID39381901
PMCPMC11610712

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.