Evidence map›Paper›PMID 39381753›Full record

ArticleiScience2024

The prion protein is required for normal responses to light stimuli by photoreceptors and bipolar cells.

James F Striebel, James A Carroll, Brent Race, Jacqueline M Leung, Cindi Schwartz, Emily D Reese, Catherine Bowes Rickman, Bruce Chesebro, Mikael Klingeborn

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

James F StriebelLaboratory of Neurological Infections and Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
James A CarrollLaboratory of Neurological Infections and Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Brent RaceLaboratory of Neurological Infections and Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Jacqueline M LeungResearch Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Cindi SchwartzResearch Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Emily D ReeseMcLaughlin Research Institute, Great Falls, MT 59405, USA.
Catherine Bowes RickmanDepartment of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA.
Bruce ChesebroLaboratory of Neurological Infections and Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Mikael KlingebornDepartment of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA.

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI W Daniel Stamer · 1985 to 2026
$19.3M
Modulation of Exosome Release for Functional Restoration in Age-related Retinal DisordersP20GM152335 · NIGMS · MC LAUGHLIN RESEARCH INSTITUTE · PI Brenda F Canine · 2024 to 2026
$11.1M
Complement factor H modulates lipoprotein clearance in AMDR01EY031748 · NEI · DUKE UNIVERSITY · PI BOWES RICKMAN, CATHERINE · 2020 to 2024
$2.8M
The Role of RPE-derived Exosomes in Deposit Formation and ECM ModulationR21EY033057 · NEI · MC LAUGHLIN RESEARCH INSTITUTE · PI KLINGEBORN, MIKAEL · 2021 to 2022
$447k
NEI NIH HHS P30 EY005722NEI NIH HHS R01 EY031748NEI NIH HHS R21 EY033057NIGMS NIH HHS P20 GM152335
6 · The paper itself

Abstract

The prion protein, PrP

Indexed as

Cell biologyMolecular biologyNeuroscienceOmicsTranscriptomics

Identifiers

PMID39381753
PMCPMC11460503

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.