Evidence map›Paper›PMID 39381598›Full record

ArticleToxicology research2024

Repeated radon exposure induced ATM kinase-mediated DNA damage response and protective autophagy in mice and human bronchial epithelial cells.

Xiaoyu Chen, Shan Shan, Aiqing Wang, Cheng Tu, Jianmei Wan, Chengjiao Hong, Xiaohan Li, Xueying Wang, Jieyun Yin, Jian Tong and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoyu ChenSchool of Public Health, Suzhou Medical College of Soochow University, 199 Renai Road, Suzhou 215123, Jiangsu, China.ORCID https://orcid.org/0000-0002-1892-6237
Shan ShanSchool of Public Health, Suzhou Medical College of Soochow University, 199 Renai Road, Suzhou 215123, Jiangsu, China.ORCID https://orcid.org/0009-0009-2298-0082
Aiqing WangSuzhou Medical College of Soochow University, 199 Renai Road, Suzhou 215123, Jiangsu, China.ORCID https://orcid.org/0009-0005-1191-3221
Cheng TuSuzhou Medical College of Soochow University, 199 Renai Road, Suzhou 215123, Jiangsu, China.ORCID https://orcid.org/0009-0008-7439-0300
Jianmei WanSuzhou Medical College of Soochow University, 199 Renai Road, Suzhou 215123, Jiangsu, China.ORCID https://orcid.org/0009-0002-3494-028X
Chengjiao HongSuzhou Medical College of Soochow University, 199 Renai Road, Suzhou 215123, Jiangsu, China.ORCID https://orcid.org/0009-0004-1901-5189
Xiaohan LiSchool of Public Health, Suzhou Medical College of Soochow University, 199 Renai Road, Suzhou 215123, Jiangsu, China.ORCID https://orcid.org/0009-0006-9208-5129
Xueying WangSchool of Public Health, Suzhou Medical College of Soochow University, 199 Renai Road, Suzhou 215123, Jiangsu, China.ORCID https://orcid.org/0000-0002-9731-6890
Jieyun YinSchool of Public Health, Suzhou Medical College of Soochow University, 199 Renai Road, Suzhou 215123, Jiangsu, China.ORCID https://orcid.org/0000-0002-5265-3930
Jian TongSchool of Public Health, Suzhou Medical College of Soochow University, 199 Renai Road, Suzhou 215123, Jiangsu, China.ORCID https://orcid.org/0009-0003-1864-2749
Hailin TianSchool of Public Health, Suzhou Medical College of Soochow University, 199 Renai Road, Suzhou 215123, Jiangsu, China.ORCID https://orcid.org/0000-0002-6891-7697
Lili XinSchool of Public Health, Suzhou Medical College of Soochow University, 199 Renai Road, Suzhou 215123, Jiangsu, China.ORCID https://orcid.org/0000-0002-7266-9657

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRadon (

methodsBiomarkers of DNA double-strand breaks (DSBs), DNA repair response to DSBs, ataxia-telangiectasia mutated (ATM) kinase, autophagy, and a cell apoptosis signaling pathway as well as cell-cycle arrest and the rate of apoptosis were determined in mouse lung and BEAS-2B cells after radon exposure.

resultsRepeated radon exposure induced DSBs indicated by the increasing expressions of γ-Histone 2AX (H2AX) protein and

conclusionsThe findings demonstrated that long-term exposure to radon gas induced DNA lesions in the form of DSBs and a series of ATM-dependent DDR pathways. Activation of the ATM-mediated autophagy may provide a protective and pro-survival effect on radon-induced DSBs.

Indexed as

ApoptosisAtaxia-telangiectasia mutated protein kinaseAutophagyCell-cycle arrestDNA damage responseNon-homologous DNA end joiningRadonγ-H2AX

Identifiers

PMID39381598
PMCPMC11457374

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.