Evidence map›Paper›PMID 39381468›Full record

ArticleCureus2024

Myelin Oligodendrocyte Glycoprotein Antibody Disease (MOGAD)-Monophasic Optic Neuritis and Epstein-Barr Virus (EBV): A Case Report of Rare Comorbid Diagnoses in an Adolescent From a Remote Greek Island.

Efstratia-Maria Georgopoulou, Myrto Palkopoulou, Dimitrios Liakopoulos, Eleni Kerazi, Angelos-Michail Kalaentzis, Vanessa Barmparoussi, Michail Kokkinos, Anastasia Kaliontzoglou, Maria Anagnostouli

Abstract readCase Reports
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Efstratia-Maria GeorgopoulouDepartment of Neurology, General Hospital of Rhodes, Rhodes, GRC.
Myrto PalkopoulouDepartment of Neurology, General Hospital of Rhodes, Rhodes, GRC.
Dimitrios LiakopoulosDepartment of Ophthalmology, General Hospital of Rhodes, Rhodes, GRC.
Eleni KeraziDepartment of Neurology, General Hospital of Rhodes, Rhodes, GRC.
Angelos-Michail KalaentzisDepartment of Neurology, General Hospital of Rhodes, Rhodes, GRC.
Vanessa BarmparoussiResearch Unit of Radiology, 2nd Department of Radiology, School of Medicine, National and Kapodistrian University of Athens, Athens, GRC.
Michail KokkinosDepartment of Ophthalmology, General Hospital of Rhodes, Rhodes, GRC.
Anastasia KaliontzoglouDepartment of Neurology, General Hospital of Rhodes, Rhodes, GRC.
Maria AnagnostouliMultiple Sclerosis and Demyelinating Diseases Unit and Center of Expertise for Rare Demyelinating and Autoimmune Diseases of the Central Nervous System, 1st Department of Neurology, "Aeginition" University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, GRC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A unique case of a female adolescent diagnosed with myelin oligodendrocyte glycoprotein (MOG) monophasic optic neuritis with Epstein-Barr virus (EBV) reactivation antibody profile on a remote Greek island is presented, highlighting the challenges of diagnosing rare conditions in rural settings and the importance of connecting centers of expertise with regional hospitals. The 16-year-old patient presented with progressive vision loss, headache, and retrobulbar pain in the right eye. Initial ophthalmological examinations showed decreased visual acuity and color vision deterioration. Magnetic resonance imaging (MRI) revealed optic perineuritis and edema. Cerebrospinal fluid (CSF) analysis excluded oligoclonal bands, and blood analysis was positive for both anti-MOG antibodies and EBV reactivation. Expert opinion and blood immunophenotyping confirmed the neuroimmunological condition. This case not only underscores the value of telemedicine in overcoming diagnostic challenges in rural settings but also contributes to the scientific discussion on neuroimmunological aspects and the potential role of EBV as an underlying factor in acquired demyelinating syndromes (ADS), beyond multiple sclerosis (MS).

Indexed as

ebvimmunophenotypemogadmultiple sclerosisneuroimmunologyoptic neuritis

Identifiers

PMID39381468
PMCPMC11461040

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.