Evidence map›Paper›PMID 39381434›Full record

ArticleClinical medicine insights. Endocrinology and diabetes2024

Primary Hyperparathyroidism With Undetectable Intact Parathyroid Hormone.

Zhixing Song, Jessica McMullin, Forest Huls, Richard Rosenthal, Sravani Bantu, Christopher Wu, Herbert Chen, Brenessa Lindeman

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical medicine insights. Endocrinology and diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Zhixing SongDepartment of Surgery, Section of Endocrine Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID https://orcid.org/0000-0001-9306-8909
Jessica McMullinDepartment of Surgery, University of Utah, Salt Lake City, UT, USA.
Forest HulsDepartment of Pathology, Division of Laboratory Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Richard RosenthalDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, AL, USA.
Sravani BantuDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID https://orcid.org/0009-0000-2682-3409
Christopher WuDepartment of Surgery, Section of Endocrine Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Herbert ChenDepartment of Surgery, Section of Endocrine Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Brenessa LindemanDepartment of Surgery, Section of Endocrine Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypercalcemia can result from either hyperparathyroidism or non-parathyroid conditions. When hypercalcemia is accompanied by undetectable parathyroid hormone (PTH) levels, hyperparathyroidism is rarely considered the diagnosis. Herein, we report the case of a 65-year-old Caucasian woman referred to our hospital for further evaluation of hypercalcemia. Her symptoms included fatigue and brain fog, with undetectable PTH levels. A comprehensive workup, including a series of laboratory and imaging tests, excluded common non-parathyroid causes such as malignancy and familial hypocalciuric hypercalcemia. Ultrasound identified a likely enlarged parathyroid gland, which was further confirmed by a sestamibi scan. After 2 weeks of cinacalcet treatment, the patient's calcium levels decreased, indicating the parathyroid gland as the likely source of hypercalcemia. Parathyroidectomy was subsequently performed, revealing a 1927 mg adenoma. Postoperatively, the patient's calcium levels normalized, PTH levels became detectable within the normal range, and her symptoms resolved, with a marked improvement in energy. This case demonstrates that primary hyperparathyroidism can present with hypercalcemia and undetectable PTH. A genetic mutation in the PTH gene within the adenoma may explain the undetectable PTH levels preoperatively.

Indexed as

case reportcinacalcetparathyroidparathyroid hormonePrimary hyperparathyroidism

Identifiers

PMID39381434
PMCPMC11459549

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