Evidence map›Paper›PMID 39381360›Full record

ArticleJGH open : an open access journal of gastroenterology and hepatology2024

Genotypes of carboxypeptidase A1 and gamma-glutamyltransferase 1 may be useful tools for the diagnosis and the predictor of worrisome features of intraductal papillary mucinous neoplasm in Japan.

Shuhei Agawa, Seiji Futagami, Ken Nakamura, Mayu Habiro, Rie Kawawa, Yuto Shinagawa, Rina Motomiya, Kumiko Kirita, Teppei Akimoto, Takeshi Onda and 5 more

Abstract read
In one paragraph

Article in JGH open : an open access journal of gastroenterology and hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shuhei AgawaDivision of Gastroenterology, Department of Internal Medicine Nippon Medical School Tokyo Japan.
Seiji FutagamiDivision of Gastroenterology, Department of Internal Medicine Nippon Medical School Tokyo Japan.ORCID https://orcid.org/0000-0003-0502-8646
Ken NakamuraDivision of Gastroenterology, Department of Internal Medicine Nippon Medical School Tokyo Japan.
Mayu HabiroDivision of Gastroenterology, Department of Internal Medicine Nippon Medical School Tokyo Japan.
Rie KawawaDivision of Gastroenterology, Department of Internal Medicine Nippon Medical School Tokyo Japan.
Yuto ShinagawaDivision of Gastroenterology, Department of Internal Medicine Nippon Medical School Tokyo Japan.
Rina MotomiyaDivision of Gastroenterology, Department of Internal Medicine Nippon Medical School Tokyo Japan.
Kumiko KiritaDivision of Gastroenterology, Department of Internal Medicine Nippon Medical School Tokyo Japan.
Teppei AkimotoDivision of Gastroenterology, Department of Internal Medicine Nippon Medical School Tokyo Japan.
Takeshi OndaDivision of Gastroenterology, Department of Internal Medicine Nippon Medical School Tokyo Japan.
Tomohide TanabeDivision of Gastroenterology, Department of Internal Medicine Nippon Medical School Tokyo Japan.
Nobue UekiDivision of Gastroenterology, Department of Internal Medicine Nippon Medical School Tokyo Japan.
Kazufumi HondaDepartment of Bioregulation Graduate School of Medicine, Nippon Medical School Tokyo Japan.
Kok-Ann GweeDepartment of Medicine, Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore.
Katsuhiko IwakiriDivision of Gastroenterology, Department of Internal Medicine Nippon Medical School Tokyo Japan.ORCID https://orcid.org/0000-0002-5558-6104

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: This study aimed to clarify whether several single-nucleotide polymorphisms (SNPs)-related chronic pancreatitis such as carboxypeptidase A1 ( Methods: We enrolled 100 patients with IPMN and 116 patients as a control. Serum p-amylase, lipase, trypsin, phospholipase A2 (PLA2), and elastase-1 levels were measured. An Olympus EUS (GF-UCT 260) was used to perform endosonography in 100 patients with IPMN. Total EUS score was evaluated using endosonography. DNA was isolated from the duodenal tissue using a commercial system and polymerase chain reaction (PCR) was performed on 7500 Fast PCR System. Results: There were no associations between glucose tolerances, lipid levels and genotypes of Conclusion: Genotypes of carboxypeptidase A1 and gamma-glutamyltransferase 1 may be useful tools for the diagnosis and the predictor of worrisome features of IPMN.

Indexed as

carboxypeptidase A1endosonographygamma‐glutamyltransferase 1intraductal papillary mucinous neoplasmsingle‐nucleotide polymorphism

Identifiers

PMID39381360
PMCPMC11458879

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.