Evidence map›Paper›PMID 39381265›Full record

ArticleMaterials today. Bio2024

Osteoinductivity enhancement by tailoring the surface chemical bond status: A strategy to mobilize host bone growth factors for

Ruiyan Li, Kan Zhang, Chuanyao Dong, Kaiwen Wang, Xinlei Gu, Yanguo Qin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ruiyan LiDepartment of Orthopaedics, and Joint International Research Laboratory of Ageing Active Strategy and Bionic Health in Northeast Asia of Ministry of Education, The Second Hospital of Jilin University, Changchun, 130041, China.
Kan ZhangState Key Laboratory of Super Hard Materials, Key Laboratory of Mobile Materials, MOE, School of Materials Science and Engineering, Jilin University, Changchun, 130012, China.
Chuanyao DongState Key Laboratory of Super Hard Materials, Key Laboratory of Mobile Materials, MOE, School of Materials Science and Engineering, Jilin University, Changchun, 130012, China.
Kaiwen WangState Key Laboratory of Super Hard Materials, Key Laboratory of Mobile Materials, MOE, School of Materials Science and Engineering, Jilin University, Changchun, 130012, China.
Xinlei GuState Key Laboratory of Super Hard Materials, Key Laboratory of Mobile Materials, MOE, School of Materials Science and Engineering, Jilin University, Changchun, 130012, China.
Yanguo QinDepartment of Orthopaedics, and Joint International Research Laboratory of Ageing Active Strategy and Bionic Health in Northeast Asia of Ministry of Education, The Second Hospital of Jilin University, Changchun, 130041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incorporation of growth factors and biomaterials is a promising strategy for improving osseointegration. However, current strategies to develop biomaterials with exogenous growth factors present disadvantages like inefficiency, difficult deployment, and potential off-target activation, making their translation into clinical practice challenging. This study reveals a bioactive N-doped tantalum carbide (TaC) solid solution film that can be used to construct a TaCN film via bionic interface engineering to recruit host bone growth factors to the wounded site and improve bone regeneration. X-ray photoelectron spectroscopy (XPS) and protein absorption analysis reveal that the performance of TaCN is related to the surface chemical bonds of films. The introduction of N to TaC causes a cascade effect wherein negative charges enrich on the TaCN surface, and the recruitment of positively charged bone growth factors around the TaCN film is facilitated. Under these circumstances, the endogenous bone growth factors enhance bone healing. The TaCN film shows an outstanding performance for

Indexed as

BioactivityBone biomaterialsEndogenous regenerationReactive sputteringSurface charge

Identifiers

PMID39381265
PMCPMC11460471

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.