ArticleTransplant international : official journal of the European Society for Organ Transplantation2024
High-Risk HLA-DQ Mismatches Are Associated With Adverse Outcomes After Lung Transplantation.
Article in Transplant international : official journal of the European Society for Organ Transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The influence of HLA matching on graft survival in lung transplant recipients is indication specific: a UNOS database analysis.The European respiratory journal · 2026Article
- Article
- Advances in HLA and Non-HLA Immune Profiling: Integrating Next-Generation Sequencing and Artificial Intelligence in Transplantation.Annals of laboratory medicine · 2026Review
- HLA-DQ7 De Novo Donor-Specific Antibodies Are Associated with Increased Risk of Chronic Lung Allograft Dysfunction After Lung Transplantation.Journal of clinical medicine · 2026Article
- The role of eplet matching in solid organ transplantation.Frontiers in transplantation · 2025Review
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Authors and funding
13 authors.
Funding
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Abstract
Human leukocyte antigen (HLA) mismatches (MM) between donor and recipient lead to eplet MM (epMM) in lung transplantation (LTX), which can induce the development of de-novo donor-specific HLA-antibodies (dnDSA), particularly HLA-DQ-dnDSA. Aim of our study was to identify risk factors for HLA-DQ-dnDSA development. We included all patients undergoing LTX between 2012 and 2020. All recipients/donors were typed for HLA 11-loci. Development of dnDSA was monitored 1-year post-LTX. EpMM were calculated using HLAMatchmaker. Differences in proportions and means were compared using Chi2-test and Students' t-test. We used Kaplan-Meier curves with LogRank test and multivariate Cox regression to compare acute cellular rejection (ACR), chronic lung allograft dysfunction (CLAD) and survival. Out of 183 patients, 22.9% patients developed HLA-DQ-dnDSA. HLA-DQ-homozygous patients were more likely to develop HLA-DQ-dnDSA than HLA-DQ-heterozygous patients (
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