Evidence map›Paper›PMID 39380942›Full record

ArticleAdvanced functional materials2024

3D Bioprinting Highly Elastic PEG-PCL-DA Hydrogel for Soft Tissue Fabrication and Biomechanical Stimulation.

Wenhan Lee, Cancan Xu, Huikang Fu, Michael Ploch, Sean D'Souza, Steve Lustig, Xiaochun Long, Yi Hong, Guohao Dai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenhan LeeDepartment of Bioengineering, Northeastern University, Boston, MA 02115, USA.
Cancan XuDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
Huikang FuDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
Michael PlochDepartment of Chemical Engineering, Northeastern University, Boston, MA 02115, USA.
Sean D'SouzaDepartment of Bioengineering, Northeastern University, Boston, MA 02115, USA.
Steve LustigDepartment of Chemical Engineering, Northeastern University, Boston, MA 02115, USA.
Xiaochun LongAugusta University, Medical College of Georgia, Augusta, GA 30912, USA.
Yi HongDepartment of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.
Guohao DaiDepartment of Bioengineering, Northeastern University, Boston, MA 02115, USA.

Funding

Molecular control of vascular smooth muscle reprogramming in arteriovenous fistula maturationR01DK135284 · NIDDK · AUGUSTA UNIVERSITY · PI Alan Dardik, Xiaochun Long · 2023 to 2026
$2.8M
Role of endothelial Sox17 in EC-SMC crosstalk and homeostatic regulation of blood vessel adaption to arterial hemodynamicsR01HL162908 · NHLBI · NORTHEASTERN UNIVERSITY · PI DAI, GUOHAO, DARDIK, ALAN · 2022 to 2025
$2.3M
Elastic printable biomaterials for 3-D bioprinting of vascular conduitR21HD090680 · NICHD · NORTHEASTERN UNIVERSITY · PI DAI, GUOHAO · 2017 to 2018
$425k
NHLBI NIH HHS R01 HL162908NICHD NIH HHS R21 HD090680NIDDK NIH HHS R01 DK135284
6 · The paper itself

Abstract

3-D bioprinting is a promising technology to fabricate custom geometries for tissue engineering. However, most bioprintable hydrogels are weak and fragile, difficult to handle and cannot mimetic the mechanical behaviors of the native soft elastic tissues. We have developed a visible light crosslinked, single-network, elastic and biocompatible hydrogel system based on an acrylated triblock copolymer of poly(ethylene glycol) PEG and polycaprolactone (PCL) (PEG-PCL-DA). To enable its application in bioprinting of soft tissues, we have modified the hydrogel system on its printability and biodegradability. Furthermore, we hypothesize that this elastic material can better transmit pulsatile forces to cells, leading to enhanced cellular response under mechanical stimulation. This central hypothesis was tested using vascular conduits with smooth muscle cells (SMCs) cultured under pulsatile forces in a custom-made bioreactor. The results showed that vascular conduits made of PEG-PCL-DA hydrogel faithfully recapitulate the rapid stretch and recoil under the pulsatile pressure from 1 to 3 Hz frequency, which induced a contractile SMC phenotype, consistently upregulated the core contractile transcription factors. In summary, our work demonstrates the potential of elastic hydrogel for 3D bioprinting of soft tissues by fine tuning the printability, biodegradability, while possess robust elastic property suitable for manual handling and biomechanical stimulation.

Indexed as

3D bioprintingelastic hydrogelmechanical stimulationsmooth muscle cellssoft tissue

Identifiers

PMID39380942
PMCPMC11458153

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.