Evidence map›Paper›PMID 39380915›Full record

ArticleOxidative medicine and cellular longevity2024

The Combined Effect of Green Tea, Saffron, Resveratrol, and Citicoline against Neurodegeneration Induced by Oxidative Stress in an

Simone Mulè, Sara Ferrari, Giorgia Rosso, Rebecca Galla, Stefania Battaglia, Valeria Curti, Claudio Molinari, Francesca Uberti

Abstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Neuroprotective Pathway Modulation by a NovelInternational journal of molecular sciences · 2025
    Article
  5. Unraveling the Effects ofInternational journal of molecular sciences · 2025
    Review
  6. Combined Effects of Diosmin, Hesperidin,International journal of molecular sciences · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Simone MulèDepartment for Sustainable Development and Ecological Transition Laboratory of Physiology, Via Sant Eusebio 37, Vercelli (VC) 13100, Italy.
Sara FerrariDepartment for Sustainable Development and Ecological Transition Laboratory of Physiology, Via Sant Eusebio 37, Vercelli (VC) 13100, Italy.
Giorgia RossoDepartment for Sustainable Development and Ecological Transition Laboratory of Physiology, Via Sant Eusebio 37, Vercelli (VC) 13100, Italy.
Rebecca GallaDepartment for Sustainable Development and Ecological Transition Laboratory of Physiology, Via Sant Eusebio 37, Vercelli (VC) 13100, Italy.
Stefania BattagliaR&D Department Kolinpharma S.p.A., Corso Europa 5, Lainate (MI) 20045, Italy.ORCID https://orcid.org/0009-0006-1390-334X
Valeria CurtiR&D Department Kolinpharma S.p.A., Corso Europa 5, Lainate (MI) 20045, Italy.ORCID https://orcid.org/0009-0001-5051-2106
Claudio MolinariDepartment for Sustainable Development and Ecological Transition Laboratory of Physiology, Via Sant Eusebio 37, Vercelli (VC) 13100, Italy.
Francesca UbertiDepartment for Sustainable Development and Ecological Transition Laboratory of Physiology, Via Sant Eusebio 37, Vercelli (VC) 13100, Italy.ORCID https://orcid.org/0000-0001-5751-270X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During ageing, the brain is vulnerable to a growing imbalance of the antioxidant defence system, resulting in increased oxidative stress. This condition may be mainly responsible for cognitive decline, resulting in synaptic transmission disruptions and the onset of neuronal dysfunction. In this context, developing efficient preventive and therapeutic strategies against increased oxidative stress and decreased antioxidant defence mechanisms should be considered a public health priority to promote healthy ageing. Therefore, the current study explored the benefits of a novel combination of green tea, saffron, trans-Reveratrol, and citicoline, called MIX, on improving intracellular processes to ameliorate the mechanisms linked to cognitive decline under oxidative stress conditions. First, the ability of MIX to cross the blood-brain barrier (BBB) was evaluated in an

Indexed as

Cognitive DysfunctionCrocusCytidine Diphosphate CholineOxidative StressResveratrolTeaAnimalsAntioxidantsHumansMiceAntioxidantsCytidine Diphosphate CholineResveratrolTea

Identifiers

PMID39380915
PMCPMC11461078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.