Evidence map›Paper›PMID 39380841›Full record

ArticleHemaSphere2024

Combined inhibition of CTPS1 and ATR is a metabolic vulnerability in p53-deficient myeloma cells.

Romane Durand, Céline Bellanger, Géraldine Descamps, Christelle Dousset, Sophie Maïga, Jennifer Derrien, Laura Thirouard, Louise Bouard, Hélène Asnagli, Philip Beer and 8 more

Abstract read
In one paragraph

Article in HemaSphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Romane DurandNantes Université, INSERM, CHU Nantes CNRS, Université d'Angers, CRCI2NA Nantes France.ORCID 0000-0002-5422-0362
Céline BellangerNantes Université, INSERM, CHU Nantes CNRS, Université d'Angers, CRCI2NA Nantes France.
Géraldine DescampsNantes Université, INSERM, CHU Nantes CNRS, Université d'Angers, CRCI2NA Nantes France.ORCID 0009-0007-3933-1834
Christelle DoussetNantes Université, INSERM, CHU Nantes CNRS, Université d'Angers, CRCI2NA Nantes France.
Sophie MaïgaNantes Université, INSERM, CHU Nantes CNRS, Université d'Angers, CRCI2NA Nantes France.
Jennifer DerrienNantes Université, INSERM, CHU Nantes CNRS, Université d'Angers, CRCI2NA Nantes France.
Laura ThirouardNantes Université, INSERM, CHU Nantes CNRS, Université d'Angers, CRCI2NA Nantes France.
Louise BouardNantes Université, INSERM, CHU Nantes CNRS, Université d'Angers, CRCI2NA Nantes France.
Hélène AsnagliStep Pharma Saint-Genis-Pouilly France.
Philip BeerStep Pharma Saint-Genis-Pouilly France.
Andrew ParkerStep Pharma Saint-Genis-Pouilly France.
Patricia Gomez-BougieNantes Université, INSERM, CHU Nantes CNRS, Université d'Angers, CRCI2NA Nantes France.ORCID 0000-0002-4846-4782
Marie-Claire DevilderNantes Université, INSERM, CHU Nantes CNRS, Université d'Angers, CRCI2NA Nantes France.
Philippe MoreauNantes Université, INSERM, CHU Nantes CNRS, Université d'Angers, CRCI2NA Nantes France.
Cyrille TouzeauNantes Université, INSERM, CHU Nantes CNRS, Université d'Angers, CRCI2NA Nantes France.
Agnès Moreau-AubryNantes Université, INSERM, CHU Nantes CNRS, Université d'Angers, CRCI2NA Nantes France.ORCID 0000-0001-5540-3374
David ChironNantes Université, INSERM, CHU Nantes CNRS, Université d'Angers, CRCI2NA Nantes France.ORCID 0000-0002-2199-752X
Catherine Pellat-DeceunynckNantes Université, INSERM, CHU Nantes CNRS, Université d'Angers, CRCI2NA Nantes France.ORCID 0000-0002-6287-8148

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In multiple myeloma, as in B-cell malignancies, mono- and especially bi-allelic

Identifiers

PMID39380841
PMCPMC11460984

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.