Evidence map›Paper›PMID 39380725›Full record

ArticleMatrix biology plus2024

Obesity-driven changes in breast tissue exhibit a pro-angiogenic extracellular matrix signature.

Ellen E Bamberg, Mark Maslanka, Kiran Vinod-Paul, Sharon Sams, Erica Pollack, Matthew Conklin, Peter Kabos, Kirk C Hansen

Erratum issuedAbstract read
In one paragraph

Article in Matrix biology plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ellen E BambergDepartment of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Mark MaslankaDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Kiran Vinod-PaulDepartment of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Sharon SamsDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Erica PollackDepartment of Radiology and Medical Imaging, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Matthew ConklinDepartment of Cell and Regenerative Biology, School of Medicine and Public Health, Carbone Cancer Center (Tumor Microenvironment Program), University of Wisconsin, Madison, WI, USA.
Peter KabosDepartment of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Kirk C HansenDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Training Program in Cancer BiologyT32CA190216 · NCI · UNIVERSITY OF COLORADO DENVER · PI Craig T. Jordan · 2016 to 2026
$3.5M
Novel dietary interventions for reducing obesity-associated breast cancerR01CA258766 · NCI · UNIVERSITY OF COLORADO DENVER · PI VICTORIA A CATENACCI, Peter Kabos · 2022 to 2026
$3.1M
NCI NIH HHS R01 CA258766NCI NIH HHS T32 CA190216NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

Obesity has reached epidemic proportions in the United States, emerging as a risk factor for the onset of breast cancer and a harbinger of unfavorable outcomes [1], [2], [3]. Despite limited understanding of the precise mechanisms, both obesity and breast cancer are associated with extracellular matrix (ECM) rewiring [4], [5], [6]. Utilizing total breast tissue proteomics, we analyzed normal-weight (18.5 to < 25 kg/m

Indexed as

AdipocytesBody Mass IndexBreastExtracellular matrixFibroblastsGalectinLGALS1LGALS3ObesityPeroxidasinPXDNStromal cellsTissue ProteomicsTumor Microenvironment

Identifiers

PMID39380725
PMCPMC11460480

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.