Evidence map›Paper›PMID 39380592›Full record

SynthesisRevista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia2024

Immunosuppressants in women with repeated implantation failure in assisted reproductive techniques: a systematic review and meta-analysis.

Ana Clara Felix de Farias Santos, Fernanda Valeriano Zamora, Lubna Al-Sharif, Kush Sehgal, Deyvid Vieira Silva Cavalcante, Sarah Hasimyan Ferreira, Pedro Henrique Costa Matos da Silva

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ana Clara Felix de Farias SantosUniversidade Cidade de São Paulo São PauloSP Brazil Universidade Cidade de São Paulo, São Paulo, SP, Brazil.ORCID https://orcid.org/0009-0004-0007-0866
Fernanda Valeriano ZamoraUniversidade Federal de Minas Gerais Belo HorizonteMG Brazil Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID https://orcid.org/0009-0008-9861-0670
Lubna Al-SharifAn-Najah National University NablusWB Palestine An-Najah National University, Nablus, WB, Palestine.ORCID https://orcid.org/0000-0002-2129-4891
Kush SehgalTeerthanker Mahaveer University MoradabadUP India Teerthanker Mahaveer University, Moradabad, UP, India.ORCID https://orcid.org/0009-0002-0308-3481
Deyvid Vieira Silva CavalcanteUniversidade CEUMA São LuisMA Brazil Universidade CEUMA, São Luis, MA, Brazil.ORCID https://orcid.org/0000-0002-0329-2219
Sarah Hasimyan FerreiraDepartamento de Ginecologia e Obstetrícia Faculdade de Medicina Universidade Federal de Goiás GoiâniaGO Brazil Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, GO, Brazil.ORCID https://orcid.org/0000-0001-9424-6009
Pedro Henrique Costa Matos da SilvaDepartamento de Ginecologia e Obstetrícia Faculdade de Medicina Universidade Federal de Goiás GoiâniaGO Brazil Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, GO, Brazil.ORCID https://orcid.org/0000-0002-2707-9324

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To compare outcomes in patients with repeated implantation failure undergoing Intracytoplasmic Sperm Injection/In vitro fertilization (IVF/ICSI) plus immunosuppressants such as prednisolone, prednisone, or cyclosporine A versus the use of IVF/ICSI alone. Data source: Databases were systematically searched in PubMed, Cochrane, and Embase databases in September 2023. Study Selection: Randomized clinical trials and observational studies with the outcomes of interest were included. Data collect: We computed odds ratios (ORs) for binary endpoints, with 95% confidence intervals (CIs). Heterogeneity was assessed using I Data synthesis: Seven studies with 2,829 patients were included. Immunosuppressive treatments were used in 1,312 (46.37%). Cyclosporine A improved implantation rate (OR 1.48; 95% CI 1.01-2.18) and clinical pregnancy (1.89, 95% CI 1.14-3.14). Compared to non-immunosuppressive treatment, prednisolone and prednisone did not improve live birth (OR 1.13, 95% CI 0.88-1.46) and miscarriage (OR 1.49, 95% CI 1.07-2.09). Prednisolone showed no significant effect in patients undergoing IVF/ICSI, clinical pregnancy (OR 1.34; 95% CI 0.76-2.36), or implantation rate (OR 1.36; 95% CI 0.76-2.42). Conclusion: Cyclosporine A may promote implantation and clinical pregnancy rates. However, given the limited sample size, it is important to approach these findings with caution. Our results indicate that prednisolone and prednisone do not have any beneficial effects on clinical outcomes of IVF/ICSI patients with repeated implantation failure. PROSPERO: CRD42023449655.

Indexed as

Embryo ImplantationImmunosuppressive AgentsReproductive Techniques, AssistedCyclosporineFemaleHumansPrednisolonePrednisonePregnancyPregnancy RateSperm Injections, IntracytoplasmicCyclosporineImmunosuppressive AgentsPrednisolonePrednisoneCyclosporine APrednisolone Immunosupressive agentsPrednisoneRepeated implantation failureReproductionReproductive techniques, assisted

Identifiers

PMID39380592
PMCPMC11460425

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.