Evidence map›Paper›PMID 39380247›Full record

ArticleJournal of inherited metabolic disease2025

Genetically humanized phenylketonuria mouse model as a testing tool for human genome editing in fertilized eggs.

Atsumi Tsuji-Hosokawa, Iku Tsuchiya, Kie Shimizu, Miho Terao, Mito Yasuhara, Natsuho Miyamoto, Saki Kikuchi, Yuya Ogawa, Kazuaki Nakamura, Yoichi Matsubara and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inherited metabolic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Atsumi Tsuji-HosokawaDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan.ORCID 0000-0001-8226-2618
Iku TsuchiyaDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan.
Kie ShimizuDepartment of Pharmacology, National Research Institute for Child Health and Development, Tokyo, Japan.ORCID 0009-0008-3716-9279
Miho TeraoDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan.
Mito YasuharaDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan.
Natsuho MiyamotoDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan.
Saki KikuchiDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan.
Yuya OgawaDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan.
Kazuaki NakamuraDepartment of Pharmacology, National Research Institute for Child Health and Development, Tokyo, Japan.ORCID 0000-0003-4999-5056
Yoichi MatsubaraNational Center for Child Health and Development, Setagaya, Tokyo, Japan.ORCID 0000-0001-5990-8214
Shuji TakadaDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo, Japan.ORCID 0000-0002-9406-4683

Funding

Japan Agency for Medical Research and Development 19ek0109290h0003Japan Society for the Promotion of Science 20K18208National Research Institute for Child Health and Development 2023C-12
6 · The paper itself

Abstract

Targeted genome editing has made significant advancements; however, safety and ethical issues have not been fully elucidated, resulting in strict control of the technique. We tested genome editing tools on gametes from a genetically humanized mouse model using a phenylketonuria (PKU) mouse model to gain insights into genome editing in human embryos. The human PKU mouse model Pah

Indexed as

Gene EditingPhenylalanine HydroxylasePhenylketonuriasZygoteAnimalsCRISPR-Cas SystemsDisease Models, AnimalFemaleHumansMaleMiceMice, TransgenicPhenotypePhenylalanine Hydroxylasegenetically humanized mouse modelgenome editingphenylketonuria

Identifiers

PMID39380247
PMCPMC11729594

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.