Evidence map›Paper›PMID 39380223›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2024

Protective effect of Zhizi Huangqi Shanzha formula on aflatoxin poisoning in mice and its effect on intestinal flora.

Sun Chuanbo, X U Guangpei, Jiang Ping, Huang Shipping, Chen Cunwu, H E Yanfei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sun ChuanboCollege of Biotechnology and Pharmaceutical Engineering, West Anhui University, Lu'an 237012, China.
X U GuangpeiCollege of Biotechnology and Pharmaceutical Engineering, West Anhui University, Lu'an 237012, China.
Jiang PingCollege of Biotechnology and Pharmaceutical Engineering, West Anhui University, Lu'an 237012, China.
Huang ShippingCollege of Biotechnology and Pharmaceutical Engineering, West Anhui University, Lu'an 237012, China.
Chen CunwuCollege of Biotechnology and Pharmaceutical Engineering, West Anhui University, Lu'an 237012, China.
H E YanfeiCollege of Biotechnology and Pharmaceutical Engineering, West Anhui University, Lu'an 237012, China.

Funding

Natural Science Research Project for Anhui Universities-mechanism of Anti-bacterial Diarrhea Effect of Probiotic-fermented Portulaca Oleracea in Targeting and Regulating Amino acid Metabolism of Intestinal Flora and Screening of Anti-tumor Active Fraction of Paris polyphylla and its Effect on the Tumour Immune Microenvironment 2022AH051668Natural Science Research Project for Anhui Universities-mechanism of Anti-bacterial Diarrhea Effect of Probiotic-fermented Portulaca Oleracea in Targeting and Regulating Amino acid Metabolism of Intestinal Flora and Screening of Anti-tumor Active Fraction of Paris polyphylla and its Effect on the Tumour Immune Microenvironment 2023AH052634Provincial Natural Science Foundation of Anhui Province-Quantitative Constitutive Effect and Mechanism of Action of Dendrobium Polysaccharides against Tumours based on the Tumour Microenvironment 2208085QH273
6 · The paper itself

Abstract

objectiveTo evaluate the protective effect of Zhizi Huangqi Shanzha formula (, ZHSF) on aflatoxin-induced liver injury.

methodsThe protective effect of ZHSF on the aflatoxin-induced liver injury was evaluated by histological observation, blood cell analysis, evaluation of liver function and immunity, and gut microbiota analysis.

resultsZHSF can significantly up-regulate the percentage of lymphocytes and eosinophils in the blood of Aflatoxin B1-intoxicated mice, down-regulate the levels of serum aspartate aminotransferase, alanine aminotransferase, and malondialdehyde, and recover the liver tissue structure. Aflatoxin poisoning induces a variation of the intestinal flora of mice, and ZHSF may recover the variation of intestinal flora induced by Aflatoxin B1. Cluster analysis showed that the intestinal flora of mice in the intervention group was more similar to that of the control group. Correlation analysis showed that Lachnospiraceae, Desulfovibrio, and Lactobacillus may be the key flora for the pharmacological effects of ZHSF.

conclusionsZHSF may protect against aflatoxin-induced liver damage, improve immunity, and inhibit oxidative stress by regulating the composition and relative abundance of intestinal flora, which makes it a promising liver-protective candidate drug.

Indexed as

AflatoxinsDrugs, Chinese HerbalGastrointestinal MicrobiomeAflatoxin PoisoningAlanine TransaminaseAnimalsAspartate AminotransferasesBacteriaChemical and Drug Induced Liver InjuryHumansLiverMaleMalondialdehydeMiceProtective AgentsAflatoxinsAlanine TransaminaseAspartate AminotransferasesDrugs, Chinese HerbalMalondialdehydeProtective Agentsaflatoxicosisgastrointestinal microbiomeliver injurymiceprotective effectZhizi Huangqi Shanzha formula

Identifiers

PMID39380223
PMCPMC11462521

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.