Evidence map›Paper›PMID 39380126›Full record

ArticlePorcine health management2024

Detection and quantification by molecular techniques of early infection by Lawsonia intracellularis in suckling piglets.

Víctor Rodriguez-Vega, Héctor Puente, Ana Carvajal, Lucía Pérez-Pérez, Samuel Gómez-Martínez, Fernando L Leite, Rocío García, Lola Abella, Héctor Argüello

Abstract read
In one paragraph

Article in Porcine health management, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Víctor Rodriguez-VegaBoehringer Ingelheim Animal Health España, Barcelona, Spain. victor_2.rodriguez@boehringer-ingelheim.com.
Héctor PuenteDepartamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, León, Spain.
Ana CarvajalDepartamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, León, Spain.
Lucía Pérez-PérezDepartamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, León, Spain.
Samuel Gómez-MartínezDepartamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, León, Spain.
Fernando L LeiteBoehringer Ingelheim Animal Health USA Inc, Duluth, GA, USA.
Rocío GarcíaBoehringer Ingelheim Animal Health España, Barcelona, Spain.
Lola AbellaCárnicas Tabladillo, Segovia, Spain.
Héctor ArgüelloDepartamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, León, Spain.

Funding

Ministerio de Educación y Formación Profesional PRE2020-093762
6 · The paper itself

Abstract

backgroundLawsonia intracellularis is the causative agent of Porcine Proliferative Enteropathy (PPE), one of the most prevalent pig enteric diseases worldwide, but with sparse information about early infections in suckling piglets in the epidemiology of PPE. With that aim, this study evaluates the prevalence of L. intracellularis in 3-week-old piglets by analysing ileal digesta content and mucosal scrapings from 383 pigs from 16 farms (aprox., 25 pigs/batch) by real-time qPCR and droplet digital PCR (ddPCR).

resultsForty-nine samples yielded a qPCR positive result. Eleven samples from eight farms were confirmed as positive with concentrations of L. intracellularis from 3.5 log

conclusionsThe results of the study demonstrate that a number of piglets are already infected with L. intracellularis during the suckling period evidencing early infection in certain animals, adding information of PPE epidemiology and opening new research topics such as sow-piglet transmission. Study results also evidence the usefulness of a combination of qPCR and ddPCR to improve qPCR sensitivity but assuring high specificity.

Indexed as

Enteric infectionIleitisPathogenPorcine proliferative enteropathySwineTransmission

Identifiers

PMID39380126
PMCPMC11459964

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.