ArticleDiabetology & metabolic syndrome2024
Atherogenic index of plasma and obesity-related risk of stroke in middle-aged and older Chinese adults: a national prospective cohort study.
Article in Diabetology & metabolic syndrome, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Joint association of atherogenic index of plasma (AIP) and body roundness index (BRI) with cardiometabolic multimorbidity in adults in Guangzhou, China.Cardiovascular diabetology · 2026Article
- Remnant Cholesterol Inflammatory Index and Its Association With All-Cause Mortality Among General Population and Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: Evidence From Two Nationwide Studies.Clinical cardiology · 2026Article
- Association of the atherogenic index of plasma and a novel triglyceride-glucose-body shape index with stroke: insights from NHANES and machine learning approaches.BMC cardiovascular disorders · 2026Article
- Atherogenic index of plasma in stroke: A comprehensive review of its diagnostic, prognostic, and pathophysiological significance.World journal of clinical cases · 2026Review
- Remnant cholesterol inflammatory index and its association with new-onset chronic diseases: evidence from two nationwide studies.Journal of health, population, and nutrition · 2026Article
- Insights into the complex relationship between body roundness index, atherogenic index of plasma, and stroke: a nationwide prospective cohort study.Lipids in health and disease · 2026Article
- Association of the atherogenic index of plasma with the risk of cardiovascular disease and death among diabetic or prediabetic adults.Endocrine · 2025Article
- Association between eGDR and accelerated aging: the mediating role of ePWV.Diabetology & metabolic syndrome · 2025Article
- Association between atherogenic index of plasma and new-onset stroke in a population with cardiovascular-kidney-metabolic syndrome stages 0-3: insights from CHARLS.Cardiovascular diabetology · 2025Article
- Joint Association of Remnant Cholesterol and Body Mass Index with Hypertension: A National Cohort Study in Chinese Adults.Journal of multidisciplinary healthcare · 2025Article
- Association between the atherogenic index of plasma, body mass index, and cardiovascular diseases in Chinese middle and old-aged adults: a mediation analysis.Frontiers in cardiovascular medicine · 2025Article
- Joint association of sleep duration and depression with new-onset hearing loss: a national cohort study.Frontiers in nutrition · 2025Article
- Joint association of estimated glucose disposal rate and body mass index with new-onset stroke.Frontiers in neurology · 2025Article
- Joint association of frailty and depression with new-onset digestive disease among elderly Chinese population.Frontiers in nutrition · 2025Article
- Association between the atherogenic index of plasma and risk of large-artery atherosclerotic ischemic stroke.Frontiers in neurology · 2025Article
- Nonlinear relationship between incidence of new-onset stroke and plasma atherosclerotic index in middle-aged and older adults.Frontiers in neurology · 2025Article
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Abstract
backgroudThe association between the atherogenic index of plasma (AIP) and stroke risk is uncertain. Overweight and obese individuals frequently develop atherosclerosis, suggesting AIP may mediate the relationship between body mass index (BMI) and stroke risk. This study investigates whether AIP mediates the BMI-stroke association and evaluates the interaction effects of AIP and BMI on stroke risk in middle-aged and older Chinese adults.
methodThis study analyzes data from the China Health and Retirement Longitudinal Study (CHARLS), an ongoing nationally representative prospective cohort study that began in 2011. It includes 8 598 middle-aged and older Chinese adults without stroke at baseline. A mediation analysis, employing a novel two-stage regression method, was conducted to evaluate the indirect effect of BMI on stroke through AIP.
resultsDuring a median follow-up of 7.1 years, 615 (7.2%) participants developed a stroke. After adjusting for confounders, AIP was significantly associated with stroke risk (hazard ratio [HR] per 1-SD increase, 1.24; 95% CI 1.14-1.35). Mediation analysis indicated that compared to normal weight, obesity similarly raised stroke risk by 78.0% (HR 1.78, 95% CI 1.40-2.27), with 29.67% (95% CI 14.27-45.08%) of the association mediated through AIP (HR 1.15, 95% CI 1.08-1.23). No significant multiplicative or additive interactions were observed between BMI and AIP on stroke.
conclusionsThis study found that the AIP appeared to be associated with stroke risk and mediates the association between obesity and stroke among middle-aged and older Chinese adults.
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