Evidence map›Paper›PMID 39380064›Full record

ArticleJournal of neuroinflammation2024

IL-7Rα on CD4

Gholamreza Azizi, Bram Van den Broek, Larissa Lumi Watanabe Ishikawa, Hamed Naziri, Reza Yazdani, Guang-Xian Zhang, Bogoljub Ciric, Abdolmohamad Rostami

Abstract read
In one paragraph

Article in Journal of neuroinflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Robust CD4medRxiv : the preprint server for health sciences · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gholamreza AziziDepartment of Neurology, Thomas Jefferson University, 900 Walnut Street, Suite 300, Philadelphia, PA, 19107, USA.
Bram Van den BroekDepartment of Neurology, Thomas Jefferson University, 900 Walnut Street, Suite 300, Philadelphia, PA, 19107, USA.
Larissa Lumi Watanabe IshikawaDepartment of Neurology, Thomas Jefferson University, 900 Walnut Street, Suite 300, Philadelphia, PA, 19107, USA.
Hamed NaziriDepartment of Neurology, Thomas Jefferson University, 900 Walnut Street, Suite 300, Philadelphia, PA, 19107, USA.
Reza YazdaniDepartment of Neurology, Thomas Jefferson University, 900 Walnut Street, Suite 300, Philadelphia, PA, 19107, USA.
Guang-Xian ZhangDepartment of Neurology, Thomas Jefferson University, 900 Walnut Street, Suite 300, Philadelphia, PA, 19107, USA.
Bogoljub CiricDepartment of Neurology, Thomas Jefferson University, 900 Walnut Street, Suite 300, Philadelphia, PA, 19107, USA.
Abdolmohamad RostamiDepartment of Neurology, Thomas Jefferson University, 900 Walnut Street, Suite 300, Philadelphia, PA, 19107, USA. a.m.rostami@jefferson.edu.

Funding

Role of IL-7R in CNS autoimmunityR01AI156384 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI A.M. Rostami · 2021 to 2026
$1.9M
NIAID NIH HHS R01 AI156384
6 · The paper itself

Abstract

backgroundThe IL-7 receptor alpha (IL-7Rα) binds both IL-7 and thymic stromal lymphopoietin (TSLP). IL-7Rα is essential for the development and survival of naive CD4

methodsWe generated Il7ra

resultsLoss of IL-7Rα from the surface of CD4

conclusionOur study demonstrates that IL-7Rα on peripheral CD4

Indexed as

CD4-Positive T-LymphocytesEncephalomyelitis, Autoimmune, ExperimentalMice, Inbred C57BLMice, TransgenicReceptors, Interleukin-7AnimalsCell SurvivalCytokinesMiceMice, KnockoutMyelin-Oligodendrocyte GlycoproteinPeptide FragmentsCytokinesinterleukin-7 receptor, alpha chainMyelin-Oligodendrocyte Glycoproteinmyelin oligodendrocyte glycoprotein (35-55)Peptide FragmentsReceptors, Interleukin-7CD4+ T cellExperimental autoimmune encephalomyelitisIL-7 receptor alphaMultiple sclerosis

Identifiers

PMID39380064
PMCPMC11460225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.