Evidence map›Paper›PMID 39380015›Full record

Trial reportJournal of orthopaedic surgery and research2024

Systemic iodine levels increase with povidone-iodine irrigation, but does this affect thyroid functions? A case-control study.

Mehmet Batu Ertan, Kerem Başarır, Hakan Kocaoğlu, Mehmet Yağız Ayduğan, Erdal Güngör

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of orthopaedic surgery and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05599841 (Evaluation of the Systemic Effect of Intraoperative Diluted Povidone Iodine Irrigation Using Urine Iodine and Thyroid Function Tests in Patients Undergoing Knee-Hip Arthroplasty), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05599841 naunknown statusnot on this map

Evaluation of the Systemic Effect of Intraoperative Diluted Povidone Iodine Irrigation Using Urine Iodine and Thyroid Function Tests in Patients Undergoing Knee-Hip Arthroplasty

TypeinterventionalSponsorAnkara UniversityRan2019 to 2023Enrolled120ConditionsOsteoarthritis, Hyperthyroidism, Iodine ToxicityArmsPI solution, Saline Solution
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mehmet Batu ErtanDepartment of Orthopedics and Traumatology, Atilim University School of Medicine, Ankara, Turkey. mbatuertan@gmail.com.
Kerem BaşarırDepartment of Orthopedics and Traumatology, Halic University School of Medicine, Istanbul, Turkey.
Hakan KocaoğluDepartment of Orthopedics and Traumatology, Ankara University School of Medicine, Ankara, Turkey.
Mehmet Yağız AyduğanDepartment of Orthopedics and Traumatology, Ministry of Health Haymana State Hospital, Ankara, Turkey.
Erdal GüngörDepartment of Orthopedics and Traumatology, Istanbul Medipol University, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntraoperative irrigation with diluted povidone iodine (PI) can be used to reduce the incidence of infection-related complications in arthroplasty surgeries. Since PI is associated with many interventions, especially skin antisepsis, its systemic effects are being studied. The aim of our study is to evaluate the systemic effects of PI, which we use as an irrigation solution, by means of urine iodine and thyroid function tests.

methodsIn this case-control study, 96 patients who underwent knee or hip arthroplasty were included and divided into two groups according to the irrigation solution. In the first group, PI was added to the standard irrigation. The second group was considered as the control group and only standard irrigation was applied. Urine iodine, thyroid stimulating hormone, free T3 and free T4 values were compared in the preoperative and postoperative periods of these two groups. In this way, the effect of absorbed iodine on thyroid functions was investigated.

resultsIn the diluted PI group, urinary iodine levels were measured at maximum levels (450 µg/L) in the early postoperative period in most of the patients. The statistically significant difference in urinary iodine levels between the PI group and the control group, which started in the early postoperative period, continued until the last follow-up on the 14th postoperative day. In terms of thyroid functions, the observed differences were not statistically significant.

conclusionStudies to reduce periprosthetic infection show that PI can be preferred for irrigation before the closure of the joint area in total joint arthroplasty. Although the success of this treatment in periprosthetic infection has been investigated, its systemic examination has not been demonstrated. It was determined that PI treatment, which was seen to decrease in the systemic circulation within 14 days, did not show a statistically significant change in terms of thyroid functions when used at the determined concentration and duration. These results should be evaluated with larger and longer-term studies.

trial registrationClinical trials ID no. NCT05599841.

Indexed as

Anti-Infective Agents, LocalArthroplasty, Replacement, HipIodinePovidone-IodineTherapeutic IrrigationThyroid GlandAgedAged, 80 and overArthroplasty, Replacement, KneeCase-Control StudiesFemaleHumansMaleMiddle AgedThyroid Function TestsAnti-Infective Agents, LocalIodinePovidone-IodinePeriprosthetic joint infectionPovidone iodineThyroid functionsUrine iodine

Identifiers

PMID39380015
PMCPMC11462707

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.