Evidence map›Paper›PMID 39380004›Full record

Observational studyRadiation oncology (London, England)2024

Radio-opaque contrast agents for liver cancer targeting with KIM during radiation therapy (ROCK-RT): an observational feasibility study.

Natalie Plant, Adam Mylonas, Chandrima Sengupta, Doan Trang Nguyen, Shona Silvester, David Pryor, Peter Greer, Yoo Young Dominique Lee, Prabhakar Ramachandran, Venkatakrishnan Seshadri and 5 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Radiation oncology (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05169177 (Radio-opaque Contrast Agents for Liver Cancer Targeting With KIM During Radiation Therapy), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05169177 recruitingnot on this map

Radio-opaque Contrast Agents for Liver Cancer Targeting With KIM During Radiation Therapy

TypeobservationalSponsorUniversity of SydneyRan2022 to 2026Enrolled50ConditionsLiver Neoplasm
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Natalie PlantImage X Institute, University of Sydney, Suite 201, Biomedical Building (C81), 1 Central Ave, Eveleigh, NSW, 2015, Australia.
Adam MylonasImage X Institute, University of Sydney, Suite 201, Biomedical Building (C81), 1 Central Ave, Eveleigh, NSW, 2015, Australia.
Chandrima SenguptaImage X Institute, University of Sydney, Suite 201, Biomedical Building (C81), 1 Central Ave, Eveleigh, NSW, 2015, Australia.
Doan Trang NguyenImage X Institute, University of Sydney, Suite 201, Biomedical Building (C81), 1 Central Ave, Eveleigh, NSW, 2015, Australia.
Shona SilvesterImage X Institute, University of Sydney, Suite 201, Biomedical Building (C81), 1 Central Ave, Eveleigh, NSW, 2015, Australia.
David PryorDepartment of Radiation Oncology, Princess Alexandra Hospital, Brisbane, QLD, Australia.
Peter GreerDepartment of Radiation Oncology, Calvary Mater Newcastle, Newcastle, NSW, Australia.
Yoo Young Dominique LeeDepartment of Radiation Oncology, Princess Alexandra Hospital, Brisbane, QLD, Australia.
Prabhakar RamachandranDepartment of Radiation Oncology, Princess Alexandra Hospital, Brisbane, QLD, Australia.
Venkatakrishnan SeshadriDepartment of Radiation Oncology, Princess Alexandra Hospital, Brisbane, QLD, Australia.
Yuvnik TradaDepartment of Radiation Oncology, Calvary Mater Newcastle, Newcastle, NSW, Australia.
Richard KhorOlivia Newton-John Cancer Wellness & Research Centre, Austin Health, Melbourne, VIC, Australia.
Tim WangDepartment of Radiation Oncology, Crown Princess Mary Cancer Centre, Sydney, NSW, Australia.
Nicholas HardcastlePeter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Paul KeallImage X Institute, University of Sydney, Suite 201, Biomedical Building (C81), 1 Central Ave, Eveleigh, NSW, 2015, Australia. paul.keall@sydney.edu.au.

Funding

Cancer Institute NSW 2019/TPG2165National Health and Medical Research Council APP1194004
6 · The paper itself

Abstract

backgroundThis observational study aims to establish the feasibility of using x-ray images of radio-opaque chemoembolisation deposits in patients as a method for real-time image-guided radiation therapy of hepatocellular carcinoma.

methodsThis study will recruit 50 hepatocellular carcinoma patients who have had or will have stereotactic ablative radiation therapy and have had transarterial chemoembolisation with a radio-opaque agent. X-ray and computed tomography images of the patients will be analysed retrospectively. Additionally, a deep learning method for real-time motion tracking will be developed. We hypothesise that: (i) deep learning software can be developed that will successfully track the contrast agent mass on two thirds of cone beam computed tomography (CBCT) projection and intra-treatment images (ii), the mean and standard deviation (mm) difference in the location of the mass between ground truth and deep learning detection are ≤ 2 mm and ≤ 3 mm respectively and (iii) statistical modelling of study data will predict tracking success in 85% of trial participants. DISCUSSION: Developing a real-time tracking method will enable increased targeting accuracy, without the need for additional invasive procedures to implant fiducial markers.

trial registrationRegistered to ClinicalTrials.gov (NCT05169177) 12th October 2021.

Indexed as

Carcinoma, HepatocellularContrast MediaFeasibility StudiesLiver NeoplasmsRadiotherapy, Image-GuidedChemoembolization, TherapeuticCone-Beam Computed TomographyFemaleHumansMaleRadiosurgeryRadiotherapy Planning, Computer-AssistedRetrospective StudiesContrast MediaImage GuidanceKilovoltage Intrafraction MonitoringLiverNeoplasmsRadio-opaque contrastRadiotherapyStereotactic ablative Radiation Therapy (SABR)Transarterial chemoemobilisation (TACE)

Identifiers

PMID39380004
PMCPMC11462695

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.